XRN2 and LSM3

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		XRN2	LSM3
Description		5'-3' exoribonuclease 2	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Metal Ion Binding	RNA Binding Protein Binding U6 SnRNA 3'-end Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	MRNA Splicing, Via Spliceosome MRNA Processing Cytoplasmic MRNA Processing Body Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 27863252)	Chronotype ( 30696823) Height ( 31562340) Offspring birth weight ( 31043758)
Interacting Genes		25 interacting genes: ALDH1B1 ATRN COMT CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LSM3 MOCS3 MRPL4 MRPS10 PRAME PSMA3 RAB14 TARDBP TIPARP TOLLIP UPF2	40 interacting genes: CCND3 CDKN2D CEP95 CLNS1A CNOT7 DLX4 EEF1A1 EIF4EBP2 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 KEAP1 KLF3 LSM1 LSM10 LSM2 LSM5 LSM6 LSM7 LSM8 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD1 SNRPD3 SNRPE SNRPG TCL1A TFIP11 THOC5 UTP14A WDR77 WDR83 XPC XRN2 YBX1
Entrez ID		22803	27258
HPRD ID		10309	06283
Ensembl ID		ENSG00000088930	ENSG00000170860
Uniprot IDs		B4DZC3 Q9H0D6	P62310
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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