FCGR1A and LAT

Number of citations of the paper that reports this interaction (PubMedID 10781611)
16

Data Source:
HPRD (in vivo)

		FCGR1A	LAT
Description		Fc fragment of IgG receptor Ia	linker for activation of T cells
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft
	Molecular Function	Protein Binding IgG Binding	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Receptor-mediated Endocytosis Phagocytosis, Engulfment Immune Response Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity	MAPK Cascade Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis	GPVI-mediated activation cascade Generation of second messenger molecules
Drugs		Cetuximab Etanercept Immune Globulin Human Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Methyl aminolevulinate Sarilumab
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)
Interacting Genes		10 interacting genes: APCS CRKL CRP FCAR FCGR3A HCK HRG LAT LILRB2 SYK	33 interacting genes: CBL CD244 CD4 CD8A CREB3 EGFR FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK KASH5 LCK LCP2 LMNA MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPN6 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2
Entrez ID		2209	27040
HPRD ID		00904	03832
Ensembl ID		ENSG00000150337	ENSG00000213658
Uniprot IDs		P12314	A0A024QZD6 O43561
PDB IDs		3RJD 4W4O 4X4M 4ZNE
Enriched GO Terms of Interacting Partners?
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