FCER1G and GP6

Number of citations of the paper that reports this interaction (PubMedID 10825177)
53

Data Source:
HPRD (in vivo, in vitro)

		FCER1G	GP6
Description		Fc fragment of IgE receptor Ig	glycoprotein VI platelet
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Fc-epsilon Receptor I Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Exosome Tetraspanin-enriched Microdomain
	Molecular Function	Protein Binding IgE Receptor Activity IgE Binding IgG Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding Signaling Receptor Activity
	Biological Process	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Stimulatory C-type Lectin Receptor Signaling Pathway Neutrophil Activation Involved In Immune Response T Cell Differentiation Involved In Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Serotonin Secretion By Platelet Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Platelet Activation Osteoclast Differentiation Neutrophil Chemotaxis Receptor Internalization Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Apoptotic Process Fc-gamma Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Interleukin-3-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Positive Regulation Of Mast Cell Degranulation Neutrophil Degranulation Innate Immune Response Mast Cell Activation Positive Regulation Of Phagocytosis Leukocyte Migration Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface	Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Platelet Activation Leukocyte Migration
Pathways		GPVI-mediated activation cascade Cell surface interactions at the vascular wall Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Dectin-2 family Dectin-2 family Neutrophil degranulation Platelet Adhesion to exposed collagen	GPVI-mediated activation cascade Cell surface interactions at the vascular wall Platelet Adhesion to exposed collagen
Drugs		Benzylpenicilloyl Polylysine
Diseases
GWAS		Aggressive periodontitis ( 28449029) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 31361310 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Mean platelet volume ( 27863252) Platelet distribution width ( 27863252)	Blood protein levels ( 30072576 28240269) Breast cancer and/or colorectal cancer ( 29698419) Mean platelet volume ( 27863252) Platelet aggregation ( 20526338 29185836) Platelet distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Venous thromboembolism ( 31420334)
Interacting Genes		9 interacting genes: FCER1A FCGR3A GP6 KIR2DL4 LMNA LYN NCR1 PLCG2 SYK	7 interacting genes: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1
Entrez ID		2207	51206
HPRD ID		00916	10406
Ensembl ID		ENSG00000158869	ENSG00000088053
Uniprot IDs		P30273	Q9HCN6
PDB IDs			2GI7 5OU7 5OU8 5OU9
Enriched GO Terms of Interacting Partners?
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