SKA1 and NDC80

Number of citations of the paper that reports this interaction (PubMedID 17093495)
94

Data Source:
BioGRID (two hybrid, imaging technique)

		SKA1	NDC80
Description		spindle and kinetochore associated complex subunit 1	NDC80 kinetochore complex component
Image
GO Annotations	Cellular Component	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule Microtubule Cytoskeleton Mitotic Spindle	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Cell Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding Identical Protein Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Regulation Of Microtubule Polymerization Or Depolymerization Cell Division	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Itch intensity from mosquito bite adjusted by bite size ( 28199695) Large HDL particle concentration ( 29084231) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231)	Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		7 interacting genes: AURKB BLOC1S6 CCDC197 NDC80 SKA2 SPC24 SYCE1	46 interacting genes: AMOTL2 ATF4 ATP5PO AURKA AURKB BLOC1S6 CALCOCO1 CCHCR1 CCNH CCNK CENPH CKAP5 HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PCM1 PFDN1 PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 WASHC3 ZWINT
Entrez ID		220134	10403
HPRD ID		12689	06277
Ensembl ID		ENSG00000154839	ENSG00000080986
Uniprot IDs		A0A024R294 Q96BD8	A8K031 O14777
PDB IDs		4AJ5 4C9Y 4CA0	2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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