ALAS1 and TTC23

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ALAS1	TTC23
Description		5'-aminolevulinate synthase 1	tetratricopeptide repeat domain 23
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Cilium
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	Protein Binding
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process	Positive Regulation Of Smoothened Signaling Pathway
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs		Pyridoxal Phosphate Pyridoxal Phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		39 interacting genes: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK EP400 GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B RTL8B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	23 interacting genes: ALAS1 APP BHLHE40 CCNDBP1 CNTROB CREBZF GOLGA2 HTT KRT31 KRT40 KRTAP10-3 LDOC1 LZTS2 MAGED1 MDFI PNMA5 SELENOS SPAG5 SSX2IP TADA2A TRIM10 TRIM54 ZDHHC17
Entrez ID		211	64927
HPRD ID		00505	07777
Ensembl ID		ENSG00000023330	ENSG00000103852
Uniprot IDs		B4DVA0 P13196 Q5JAM2	Q5W5X9
PDB IDs
Enriched GO Terms of Interacting Partners?
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