Description |
AKT serine/threonine kinase 1 |
glycogen synthase kinase 3 beta |
Image |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
- ATP
- Arsenic trioxide
- Genistein
- Inositol 1,3,4,5-Tetrakisphosphate
- Resveratrol
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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- Lithium
- 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione
- SB-409513
- N-(4-Methoxybenzyl)-N'-(5-Nitro-1,3-Thiazol-2-Yl)Urea
- Staurosporine
- Indirubin-3'-Monoxime
- (3e)-6'-Bromo-2,3'-Biindole-2',3(1h,1'h)-Dione 3-Oxime
- Alsterpaullone
- Phosphoaminophosphonic Acid-Adenylate Ester
- 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
- 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione
- (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
- 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
- N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
- 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
- ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
- (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
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Diseases |
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GWAS |
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- HDL cholesterol ( 24097068)
- HDL cholesterol levels ( 28334899)
- Hippocampal volume in Alzheimer's disease dementia ( 29274321)
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Interacting Genes |
308 interacting genes:
ACAP1
ACAT2
AGAP2
AGR3
AHNAK
AHSA1
AKT1S1
AKT2
AKTIP
ALYREF
APLP2
APOH
APP
APPL1
AR
ARAF
ARFIP2
ARNT
ATXN1
AURKA
BABAM1
BAD
BCL10
BCL2L1
BCL2L11
BCL3
BECN1
BLVRA
BPGM
BRAF
BRCA1
CAMKK1
CARHSP1
CASC3
CASP3
CASP9
CBLC
CCDC88A
CCND2
CCNE1
CCNF
CCNI
CD44
CDC37
CDK4
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CEP57L1
CEP76
CHEK1
CHUK
CLASP2
CLIP3
CLK2
CNOT9
CREB1
CREBBP
CSNK2A1
CTDSP2
CTNNB1
CYLD
DAB2IP
DCTN1
DLC1
DNAJB1
DNMT1
EEF1G
EIF4EBP1
EMSY
ENO2
EP300
EPHA2
EPSTI1
ERBB2
ESR1
ESR2
EZH2
FAF1
FANCA
FANCI
FASN
FBXO31
FGFR4
FOXO1
FOXO3
FOXO4
FUS
FZR1
GAB2
GATA1
GATA2
GET4
GFAP
GJA1
GLIS2
GRB10
GRIN2A
GSK3A
GSK3B
H2BC21
H2BC3
HIF1A
HMOX1
HSP90AA1
HSP90AB1
HSPB1
HTT
IKBKB
IL13RA2
IL24
ILK
IMPDH2
IRAK1
IRS1
ITGB3
ITPR1
ITPR3
IWS1
JADE1
KANK1
KAT2A
KAT2B
KAT6A
KDELR2
KLHL3
KMT2D
KRT10
LANCL2
LATS2
LRRK2
LTB4R2
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP3K11
MAP3K5
MAP3K8
MAPK14
MAPK8
MAPK8IP1
MAPK9
MAPKAP1
MAPKAPK2
MAPT
MATK
MDM2
MDM4
METTL1
MRC2
MS4A2
MSH2
MST1R
MTA3
MTCP1
MTOR
MTUS2
MUL1
MXD1
MYC
NCF2
NCOA4
NCOR2
NF1
NF2
NGB
NOL4
NOS3
NOTCH1
NR4A1
NSD3
OSGIN1
PAK1
PDE3A
PDE3B
PDGFRA
PDHB
PDK1
PDK2
PDPK1
PEA15
PFKFB1
PFKFB2
PFKP
PHB2
PI4K2B
PIAS1
PIAS2
PICK1
PIK3CA
PIK3R1
PIP5K1C
PKN2
PLCG1
PLEKHO1
PLP1
PLXNA1
PPARGC1B
PPL
PPM1A
PPP2CA
PPP2R1A
PRG2
PRKCB
PRKCQ
PRKCZ
PRKDC
PSMC5
PTEN
PTGDS
PTPA
PTPN1
PTPN11
PTPN3
PYGO2
RAB3D
RAC1
RAF1
RARA
RASL10B
RASSF1
RGCC
RHEBL1
RNF11
RNF115
RPS6KB1
S100A14
S1PR1
SERPINB5
SETDB1
SH2B2
SH3RF1
SIRPA
SIRT1
SIRT6
SKI
SKP2
SLC9A3R1
SMAD2
SMAD3
SMAD4
SMAD7
SMARCB1
SMARCC1
SNCA
SNCB
SORBS2
SOX2
SOX4
SP1
SP3
SRC
SRPK2
SRR
SSH1
ST14
STAT1
STK11
STK3
STK4
SULT4A1
SUPT6H
SYTL1
TBC1D4
TBC1D7
TCL1A
TCL1B
TCL6
TEAD2
TERF2IP
TERT
TFF1
THEM4
THRSP
TMCC2
TNFRSF1A
TNFSF11
TNK2
TOPBP1
TP53
TRIB3
TRIM13
TRMT2B
TSC1
TSC2
TTC3
UBE2S
UCHL1
USP4
UXS1
VEGFA
VHL
VIM
WNK1
WNK4
XIAP
YAP1
YBX1
YWHAZ
ZFP36L1
ZHX1
ZNF691
ZRANB1
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223 interacting genes:
ACLY
ACSBG1
ACTL6B
ADAP1
ADIRF
AKAP11
AKT1
AKT2
AKT3
APC
APP
AR
ARRB1
ASRGL1
ATP5IF1
ATXN3
AURKA
AXIN1
AXIN2
BAG6
BCL2A1
BCL2L1
BCL3
BEX1
BHLHE41
BICD1
BICD2
BRIX1
BTRC
BZW2
CABYR
CAMSAP3
CCND1
CCNE1
CDH1
CDK5
CDX2
CEBPA
CEBPD
CEBPZ
CENPB
CHD3
CIITA
CLEC3B
CREB1
CREB3L3
CREM
CSAD
CSNK2B
CST6
CTNNB1
CTNND1
DBI
DCTN1
DCTN2
DCTN3
DDIT4
DEAF1
DEFA1
DELEC1
DHX34
DISC1
DNAJC13
DNM1L
DNMT1
DNMT3L
DPYSL2
DUSP9
DYNC1I1
E2F1
EEF1G
EFTUD2
EIF2B5
EIF4EBP1
ENTPD6
ERG28
EYA1
FAM193B
FAM83D
FBN3
FBXO7
FBXW11
FEN1
FIBP
FKBP14
FOXO1
FRAT1
FRAT2
FZD5
GBP2
GIPC1
GJB5
GNB2
GPR39
GYS1
HDAC4
HNRNPD
HSP90AA1
HSPA4
IGHM
IGSF21
IKBKG
ILK
IQCG
IRF1
JUN
KDM1A
KHSRP
KIAA1191
KIF5B
KLF2
KLF5
LMO4
LPCAT1
LRP6
LUC7L2
MAP1B
MAP3K1
MAP3K4
MAP4
MAPK1
MAPT
MARK2
MASP1
MCL1
MDM2
MED24
MICAL1
MID1IP1
MITF
MPP1
MTF2
MTOR
MUC1
MYC
MYOCD
NAT9
NBR1
NCOA3
NDRG1
NFE2L1
NFE2L2
NFE2L3
NFKB1
NIN
NOTCH1
NOTCH2
NRBP1
NSFL1C
OGA
OGT
PDE4D
PFKFB4
PHLPP1
PIAS1
PIM2
PMAIP1
PPARGC1A
PPP1R2
PRKACA
PRKCA
PRKCB
PRKCZ
PRKDC
PSEN1
PTK2
PTN
PTPN1
PXN
QARS1
RAI1
RBPJ
RCAN1
RELB
RICTOR
RPL36AL
RPLP1
RPS2
RPS6KA1
RSU1
RXRA
SAP30BP
SGK1
SGK3
SLA
SMAD3
SNAI1
SNCA
SNCAIP
SOX10
SOX9
SPTBN4
SREBF1
SYNE4
TAZ
TLE1
TMEM132A
TMEM44
TONSL
TP53
TPPP
TRAF6
TSC2
TUBA1A
UBE2D1
UBR1
UBR5
UBXN6
UFM1
UPF3A
VIM
VPS51
WSB1
XIAP
XPNPEP1
YBX1
YBX3
YWHAZ
ZFPM1
ZHX1
ZNF135
ZNF227
ZNF746
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Entrez ID |
207 |
2932 |
HPRD ID |
01261 |
05418 |
Ensembl ID |
ENSG00000142208
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ENSG00000082701
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Uniprot IDs |
B0LPE5
B3KVH4
P31749
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P49841
Q6FI27
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PDB IDs |
1H10
1UNP
1UNQ
1UNR
2UVM
2UZR
2UZS
3CQU
3CQW
3MV5
3MVH
3O96
3OCB
3OW4
3QKK
3QKL
3QKM
4EJN
4EKK
4EKL
4GV1
5KCV
6BUU
6CCY
6HHF
6HHG
6HHH
6HHI
6HHJ
6NPZ
6S9W
6S9X
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1GNG
1H8F
1I09
1J1B
1J1C
1O6K
1O6L
1O9U
1PYX
1Q3D
1Q3W
1Q41
1Q4L
1Q5K
1R0E
1UV5
2JDO
2JDR
2JLD
2O5K
2OW3
2UW9
2X39
2XH5
3CQU
3CQW
3DU8
3E87
3E88
3E8D
3F7Z
3F88
3GB2
3I4B
3L1S
3M1S
3MV5
3OW4
3PUP
3Q3B
3QKK
3SAY
3SD0
3ZDI
3ZRK
3ZRL
3ZRM
4ACC
4ACD
4ACG
4ACH
4AFJ
4B7T
4DIT
4EKK
4IQ6
4J1R
4J71
4NM0
4NM3
4NM5
4NM7
4PTC
4PTE
4PTG
5F94
5F95
5HLN
5HLP
5K5N
5KPK
5KPL
5KPM
5OY4
5T31
6B8J
6BUU
6GJO
6GN1
6H0U
6HK3
6HK4
6HK7
6NPZ
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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