ERCC1 and ERCC4

Number of citations of the paper that reports this interaction (PubMedID 8197175)
51

Data Source:
HPRD (in vivo, in vitro)

		ERCC1	ERCC4
Description		ERCC excision repair 1, endonuclease non-catalytic subunit	ERCC excision repair 4, endonuclease catalytic subunit
Image
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Nuclear Chromosome, Telomeric Region Nucleoplasm Cytoplasm ERCC4-ERCC1 Complex	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm ERCC4-ERCC1 Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding Telomerase Inhibitor Activity Identical Protein Binding Protein N-terminus Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding
	Biological Process	Meiotic Mismatch Repair Pyrimidine Dimer Repair By Nucleotide-excision Repair Replicative Cell Aging DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Mitotic Recombination Syncytium Formation Response To Oxidative Stress Spermatogenesis Response To Nutrient Cell Proliferation Male Gonad Development UV Protection Response To Sucrose Response To X-ray Multicellular Organism Aging Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Post-embryonic Hemopoiesis Multicellular Organism Growth Response To Immobilization Stress Interstrand Cross-link Repair Isotype Switching Response To Cadmium Ion Oogenesis Embryonic Organ Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Telomeric DNA-containing Double Minutes Formation Global Genome Nucleotide-excision Repair UV-damage Excision Repair T-circle Formation Positive Regulation Of T-circle Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Via Nonhomologous End Joining Response To UV UV Protection Regulation Of Autophagy Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Cellular Response To UV Interstrand Cross-link Repair Negative Regulation Of Telomerase Activity Telomeric DNA-containing Double Minutes Formation Global Genome Nucleotide-excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protection From Non-homologous End Joining At Telomere Negative Regulation Of Double-stranded Telomeric DNA Binding
Pathways		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway	HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Simvastatin-induced myopathy ( 31220337)	Alcohol consumption (drinks per week) ( 30643258) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Bilirubin levels ( 22085899) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Bitter alcoholic beverage consumption ( 31046077) Bone mineral density (total hip) ( 29883787) Conduct disorder (symptom count) ( 20585324) Egg allergy ( 25710614) Emphysema imaging phenotypes ( 26030696) Metabolic syndrome ( 20694148) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 31170924)
Interacting Genes		16 interacting genes: APP ERCC4 KIF11 MKRN3 RAD52 RPA1 RPA2 RPA3 SLX1A TRMT2B UBL7 UHRF1 USHBP1 USP45 VPS37B XPA	12 interacting genes: ERCC1 FANCG GTF2H1 KIF11 RAD52 RPA1 RPA2 SLX1A SLX4 SPTAN1 SUMO2 XPA
Entrez ID		2067	2072
HPRD ID		00533	00594
Ensembl ID		ENSG00000012061	ENSG00000175595
Uniprot IDs		A0A024R0Q6 P07992	A0A1W1GSK9 B4DXD8 Q92889
PDB IDs		1Z00 2A1I 2A1J 2JNW 2JPD 2MUT	1Z00 2A1J 2AQ0 2KN7 2MUT
Enriched GO Terms of Interacting Partners?
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