ENG and TCTEX1D4

Number of citations of the paper that reports this interaction (PubMedID 16982625)
18

Data Source:
HPRD (in vivo, two hybrid)

		ENG	TCTEX1D4
Description		endoglin	Tctex1 domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Integral Component Of Membrane Nuclear Body Receptor Complex Endothelial Microparticle	Acrosomal Vesicle Nucleus Microtubule Organizing Center Axoneme Sperm Flagellum
	Molecular Function	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor, Cytoplasmic Mediator Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Identical Protein Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding	Protein Binding Protein Phosphatase 1 Binding
	Biological Process	Chronological Cell Aging Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Positive Regulation Of Protein Phosphorylation Heart Looping Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Regulation Of Transcription, DNA-templated Cell Adhesion Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Autophosphorylation Response To Corticosteroid Positive Regulation Of Collagen Biosynthetic Process Dorsal Aorta Morphogenesis Response To Drug Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Positive Regulation Of Protein Kinase B Signaling Atrial Cardiac Muscle Tissue Morphogenesis Bone Development Extracellular Matrix Constituent Secretion Cellular Response To Mechanical Stimulus Response To Transforming Growth Factor Beta Endocardial Cushion To Mesenchymal Transition Vascular Smooth Muscle Cell Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Vascular Smooth Muscle Cell Differentiation Atrioventricular Canal Morphogenesis Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways
Drugs
Diseases		Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971) Metabolic syndrome ( 20694148)
Interacting Genes		14 interacting genes: ACVR1 ACVR2A BMP2 BMP7 CNTRL GDF2 INHBA TCTEX1D4 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3	6 interacting genes: ACVR2A ENG PPP1CA PPP1CC TGFBR2 TGFBR3
Entrez ID		2022	343521
HPRD ID		00565	15762
Ensembl ID		ENSG00000106991	ENSG00000188396
Uniprot IDs		A0A024R878 B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0	Q5JR98
PDB IDs		5HZV 5HZW 5I04
Enriched GO Terms of Interacting Partners?
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