TIGIT and NECTIN3

Number of citations of the paper that reports this interaction (PubMedID 21982860)
16

Data Source:
BioGRID (pull down)

		TIGIT	NECTIN3
Description		T cell immunoreceptor with Ig and ITIM domains	nectin cell adhesion molecule 3
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Plasma Membrane Cell-cell Junction Adherens Junction Axon Dendrite Apical Junction Complex Cell-cell Contact Zone Hippocampal Mossy Fiber To CA3 Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding	Protein Binding Signaling Receptor Activity Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of T Cell Activation	Lens Morphogenesis In Camera-type Eye Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Spermatid Development Fertilization Adherens Junction Organization Retina Morphogenesis In Camera-type Eye Establishment Of Protein Localization To Plasma Membrane Protein Localization To Cell Junction
Pathways			Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases
GWAS			Feeling hurt ( 29500382)
Interacting Genes		4 interacting genes: NECTIN2 NECTIN3 NECTIN4 PVR	13 interacting genes: AFDN KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 NECTIN1 NECTIN2 NOTCH2NLA PARD3 PVR RGS20 TIGIT
Entrez ID		201633	25945
HPRD ID		08804	08454
Ensembl ID		ENSG00000181847	ENSG00000177707
Uniprot IDs		Q495A1	Q9NQS3
PDB IDs		3Q0H 3RQ3 3UCR 3UDW 5V52	4FOM
Enriched GO Terms of Interacting Partners?
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