EMX1 and ALX4

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		EMX1	ALX4
Description		empty spiracles homeobox 1	ALX homeobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleolus Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Post-embryonic Development Cerebral Cortex Regionalization Cerebral Cortex Neuron Differentiation Neuron Differentiation Response To Drug Brain Morphogenesis Homeostasis Of Number Of Cells Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Neuron Projection Extension	Skeletal System Development Hair Follicle Development Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Embryonic Skeletal System Morphogenesis Roof Of Mouth Development
Pathways
Drugs
Diseases			Frontonasal dysplasia Enlarged parietal foramina/cranium bifidum
GWAS		Schizophrenia ( 28991256 30285260)	Blood pressure measurement (high sodium intervention) ( 24165912) Cadmium levels ( 26025379) Excessive hairiness ( 29895819) Gout ( 22179738) Male-pattern baldness ( 29146897 27182965) Monobrow ( 27182965) Response to antidepressants in depression ( 29998114) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		8 interacting genes: ALX4 ELK1 GTF2A1L HOXA10 LINC00839 POLR2D PRDM4 TP63	12 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 LEF1 SOX10 SOX2
Entrez ID		2016	60529
HPRD ID		08963	05661
Ensembl ID		ENSG00000135638	ENSG00000052850
Uniprot IDs		Q04741	Q9H161
PDB IDs			2M0C
Enriched GO Terms of Interacting Partners?
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