MARK2 and FLRT1

		MARK2	FLRT1
Description		microtubule affinity regulating kinase 2	fibronectin leucine rich transmembrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle	Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Cytoplasmic Vesicle Membrane Extracellular Matrix Cytoplasmic Vesicle Neuronal Cell Body Membrane Neuron Projection Terminus Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity	Fibroblast Growth Factor Receptor Binding Protein Binding, Bridging
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding	Cell Adhesion Fibroblast Growth Factor Receptor Signaling Pathway Dendrite Development Positive Regulation Of Synapse Assembly Neuron Projection Extension
Pathways			Downstream signaling of activated FGFR1
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)	Inflammatory bowel disease ( 23128233)
Interacting Genes		40 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 FLRT1 GAB1 GSK3B HDAC7 INCENP ISOC1 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L NUAK1 NXF1 OSBP PARD3B PARD6A PINK1 PKD1 PLAAT3 PPP2R5B PRKCE PTPRD RAB11FIP2 RNF41 RPA2 RPS6KB1 SCGB1A1 SMURF1 STK11 UTRN YWHAB YWHAQ YWHAZ	1 interacting genes: MARK2
Entrez ID		2011	23769
HPRD ID		02753	05311
Ensembl ID		ENSG00000072518	ENSG00000126500
Uniprot IDs		A0A140VJP1 A8K2S4 Q7KZI7	Q9NZU1
PDB IDs		3IEC 5EAK 5KZ7 5KZ8
Enriched GO Terms of Interacting Partners?
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