EMD and RNF123

Number of citations of the paper that reports this interaction (PubMedID 29676528)
4

Data Source:
BioGRID (enzymatic study)

		EMD	RNF123
Description		emerin	ring finger protein 123
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GO Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Spindle Microtubule Membrane Integral Component Of Membrane Spindle Pole Centrosome Nuclear Membrane Cortical Endoplasmic Reticulum	Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Actin Binding Protein Binding Cadherin Binding Beta-tubulin Binding	Ubiquitin-protein Transferase Activity Metal Ion Binding
	Biological Process	Muscle Contraction Mitotic Nuclear Envelope Reassembly Muscle Organ Development Skeletal Muscle Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Fibroblast Proliferation Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway	Protein Ubiquitination Protein Deubiquitination Proteolysis Involved In Cellular Protein Catabolic Process
Pathways		Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerisation of the Nuclear Lamina Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Ub-specific processing proteases Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Emery-Dreifuss muscular dystrophy
GWAS			Age at first birth ( 27798627) Blood protein levels ( 28240269) Body mass index ( 26426971) Crohn's disease ( 28067908) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Household income ( 31844048) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Multisite chronic pain ( 31194737) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Ulcerative colitis ( 28067908)
Interacting Genes		45 interacting genes: ABL1 ABT1 ACTB ACTG2 AEN AKAP8L BANF1 BCLAF1 BEND7 BYSL CATSPER1 CCDC33 CEP70 COPS6 CREB3 CTNNBIP1 DPPA4 EFHC2 FATE1 GMCL1 KASH5 LMNA LMO7 LPL LUZP4 MAB21L3 MAPK6 MEOX2 MTNR1A PAK5 PSME1 RNF123 SH3GL2 SH3GL3 SRC STX4 SYNE1 TRAF3IP3 TRIM42 VAPB VAV1 YTHDC1 ZFP64 ZNF165 ZNF232	14 interacting genes: CDKN1B EMD LMNA LMNB1 MTDH RB1 SMAD2 SMAD9 TMPO UBAC1 UBC UBE2D1 UBE2D2 UBE2W
Entrez ID		2010	63891
HPRD ID		02309	11499
Ensembl ID		ENSG00000102119	ENSG00000164068
Uniprot IDs		P50402	Q5XPI4
PDB IDs		1JEI 2ODC 2ODG 6GHD	2MA6
Enriched GO Terms of Interacting Partners?
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