ELAVL1 and KPNA1

Number of citations of the paper that reports this interaction (PubMedID 15342649)
50

Data Source:
HPRD (in vivo)

		ELAVL1	KPNA1
Description		ELAV like RNA binding protein 1	karyopherin subunit alpha 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite Host Cell Glutamatergic Synapse
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding AU-rich Element Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	MRNA Splicing, Via Spliceosome Protein Import Into Nucleus Regulation Of MRNA Stability Positive Regulation Of Translation MRNA Stabilization Protein Homooligomerization Negative Regulation Of Gene Silencing By MiRNA 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Process Intracellular Transport Of Virus Postsynapse To Nucleus Signaling Pathway
Pathways		HuR (ELAVL1) binds and stabilizes mRNA mRNA Splicing - Major Pathway	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		37 interacting genes: ANP32A ANP32B APOE C12orf75 CARM1 CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL7R KPNA1 KPNB1 MIRLET7B MIRLET7I NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SREK1 TNPO1 TNPO2 VCP VEGFA XIAP	39 interacting genes: ANP32A ANP32B ARNT BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LMO4 MDM2 NOSIP NUP54 NUP62 ORC4 PAX5 PKM RAG1 RANBP2 RUNX1T1 SENP2 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5 USP1
Entrez ID		1994	3836
HPRD ID		16025	02819
Ensembl ID		ENSG00000066044	ENSG00000114030
Uniprot IDs		Q15717	B3KXZ2 P52294
PDB IDs		3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3	2JDQ 3TJ3 4B18
Enriched GO Terms of Interacting Partners?
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