EIF4E and EIF4EBP3

Number of citations of the paper that reports this interaction (PubMedID 9593750)
86

Data Source:
HPRD (in vivo, in vitro)

		EIF4E	EIF4EBP3
Description		eukaryotic translation initiation factor 4E	eukaryotic translation initiation factor 4E binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	P-body Cytoplasm Cytosol MRNA Cap Binding Complex Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Cytosol	Cytoplasm Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Enzyme Binding Eukaryotic Initiation Factor 4G Binding Repressing Transcription Factor Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response RNA Export From Nucleus MRNA Export From Nucleus Translational Initiation Regulation Of Translation Negative Regulation Of Autophagy Viral Process Negative Regulation Of Translation Stem Cell Population Maintenance Lung Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle Cellular Response To Dexamethasone Stimulus Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission	Negative Regulation Of Translational Initiation
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs		7-Methyl-Gpppa 7n-Methyl-8-Hydroguanosine-5'-Diphosphate 7-Methyl-Guanosine-5'-Triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258 30679032) Daytime sleep phenotypes ( 27126917) Menopause (age at onset) ( 29773799) Sensation seeking ( 30718321)	Metabolite levels ( 23823483)
Interacting Genes		25 interacting genes: APP BIRC2 CD83 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 GEMIN5 KANK2 MAPKAPK5 MKNK1 MKNK2 PML PRDM4 PRKCA PRKCB PRKCG TDO2 TRIM27 UBXN11	2 interacting genes: EIF4E EIF4E2
Entrez ID		1977	8637
HPRD ID		00591	09149
Ensembl ID		ENSG00000151247	ENSG00000243056
Uniprot IDs		D6RBW1 P06730 Q32Q75 X5D7E3	O60516
PDB IDs		1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46 5ZJY 5ZJZ 5ZK5 5ZK7 5ZK9 5ZML
Enriched GO Terms of Interacting Partners?
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