UBR1 and DLEU1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		UBR1	DLEU1
Description		ubiquitin protein ligase E3 component n-recognin 1	deleted in lymphocytic leukemia 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Johanson-Blizzard syndrome
GWAS		MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)	Adiponectin levels ( 26299439) Adiponectin levels (BMI-adjusted) ( 26299439) Aluminium levels ( 26025379) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood urea nitrogen levels ( 31152163) Circulating odd-numbered chain saturated fatty acid levels (C19:0) ( 29738550) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 31562340 31217584) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hip circumference adjusted for BMI ( 28552196) Lipoprotein (a) levels ( 30108283) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244 21833088 27386562) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Plasma anti-thyroid peroxidase levels ( 29678681) Primary biliary cholangitis ( 26394269) Prostate-specific antigen levels ( 28139693) Triglycerides ( 30275531) Tumor necrosis factor alpha levels ( 31217265) Type 2 diabetes ( 30054458 30297969) Urinary albumin-to-creatinine ratio ( 31630189) Urinary magnesium excretion ( 31993563) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196) Weight ( 28552196)
Interacting Genes		26 interacting genes: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	20 interacting genes: ABCD4 ABCF3 ARL8B CCDC90B CEP126 COPS6 EEF1A1 EEF1G GDF9 GOPC KAT5 MED31 PSMA1 SETDB1 SHMT1 TLE1 TP53 TUBB4B UBR1 UTP14A
Entrez ID		197131	10301
HPRD ID		09342	16150
Ensembl ID		ENSG00000159459	ENSG00000176124
Uniprot IDs		Q8IWV7
PDB IDs		3NY1 5TDC
Enriched GO Terms of Interacting Partners?
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