DCP1B and EDC3

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		DCP1B	EDC3
Description		decapping mRNA 1B	enhancer of mRNA decapping 3
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol Membrane Intracellular Membrane-bounded Organelle	P-body Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Enzyme Regulator Activity	MRNA Binding Protein Binding Identical Protein Binding Phosphodiesterase Decapping Endonuclease Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Catalytic Activity Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Cytoplasmic MRNA Processing Body Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		mRNA decay by 5' to 3' exoribonuclease	mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Grapefruit juice consumption ( 31046077) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Response to gemcitabine in pancreatic cancer ( 22142827) Survival in pancreatic cancer ( 28470677)	Caffeine consumption ( 21490707) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Craniofacial microsomia ( 26853712)
Interacting Genes		9 interacting genes: DCP2 EDC3 EXOSC6 LSM8 NSMAF SMAD4 UPF2 XRN1 ZFP36	9 interacting genes: ANXA10 DCP1A DCP1B DDX6 EFHC2 REEP5 YWHAB YWHAG ZFP36
Entrez ID		196513	80153
HPRD ID		13124	07954
Ensembl ID		ENSG00000151065	ENSG00000179151
Uniprot IDs		B4DVJ6 Q8IZD4	Q96F86
PDB IDs			2VC8 2WAX 2WAY 3D3J 3D3K 6S8S
Enriched GO Terms of Interacting Partners?
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