EIF2S1 and HSPB1

Number of citations of the paper that reports this interaction (PubMedID 25277244)
18

Data Source:
BioGRID (two hybrid)

		EIF2S1	HSPB1
Description		eukaryotic translation initiation factor 2 subunit alpha	heat shock protein family B (small) member 1
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GO Annotations	Cellular Component	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot	Proteasome Complex Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Extracellular Exosome Axon Cytoplasm
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding	RNA Binding Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Protein Binding Involved In Protein Folding
	Biological Process	Translational Initiation Aging Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Protein Autophosphorylation Transmembrane Transport Positive Regulation Of Neuron Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Retina Homeostasis Regulation Of Protein Phosphorylation Regulation Of Translational Initiation Negative Regulation Of Protein Kinase Activity Response To Unfolded Protein Response To Virus Regulation Of Autophagy Viral Process Positive Regulation Of Interleukin-1 Beta Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of MRNA Stability Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Chaperone-mediated Protein Folding Platelet Aggregation Negative Regulation Of Protein Serine/threonine Kinase Activity Anterograde Axonal Protein Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling
Drugs			Apatorsen Phenethyl Isothiocyanate
Diseases			Distal hereditary motor neuropathies (dHMN)
GWAS			Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Schizophrenia ( 30285260)
Interacting Genes		24 interacting genes: CASP3 CASP6 CDC37 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12	252 interacting genes: ACAP2 ACBD6 ACTC1 ACTN1 ACTN2 ACTN4 ADCY9 ADD3 ADPRS AGAP10P AGAP3 AGAP4 AGAP5 AGAP7P AKT1 ALPI AMD1 ANAPC7 ANK1 ANKRD7 ANXA1 AP2B1 ARHGAP28 ARHGEF7 ARIH1 ARMT1 ARRDC5 ATXN10 BAG3 BICDL1 BVES C11orf98 C2orf73 CAMK1 CBX1 CCDC32 CCDC70 CCHCR1 CCNC CCNDBP1 CCNO CDC123 CDK5RAP3 CENPK CEP78 CETN3 CFAP251 CLCN3 CPSF3 CRNKL1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX DES DMAP1 DNAJC21 ECPAS EHD1 EIF1AX EIF2S1 EIF3M EIF4G1 EIF4G3 EIF5 ENPP2 EPB41L1 EPB41L2 EPB41L3 ERCC5 ERICH6 ESR1 FAM71D FLNB FXR1 GAPVD1 GDI2 GLMN GNPAT GOLGA8A GRIPAP1 GRK3 GSTO1 GTSF1 GUCA1A HAUS8 HDLBP HECTD1 HNRNPA2B1 HNRNPD HNRNPF HNRNPU HSP90AB1 HSPA4 HSPA5 HSPB8 HUWE1 IARS2 IGBP1 IGSF21 INPP5K INS ISG20L2 KANSL1 KCMF1 KCTD3 KLC1 KNSTRN KPNA3 KRT18 KRT72 LBP LIG1 LONRF1 LRIF1 LSM3 LUZP1 MAPK14 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPT MCM6 MDH2 MED31 MFAP1 MPHOSPH6 MRGBP MRPL28 MRPL40 MRPS23 MSL1 MTIF2 MYG1 MYL12A MYL12B MYL9 MYLK NAP1L1 NAPA NBAS NCKIPSD NEK10 NEXN NFKBIA NFU1 NSMCE4A NVL OBSL1 OPTN OSBPL9 PAF1 PALM3 PELO PGM2 PHYHIPL PLG PNISR PNPT1 POP7 PPA1 PPM1A PPP2R3C PRKD1 PRPF19 PRPF40A PSMA3 PSMA6 PSMB2 PSMC1 PSMD1 PTGES3 PTPN3 PTPRA RAB41 RAD23A RALA RASSF9 RBM25 RBM39 RBM48 RBPJ RPAP3 RPSA RSPH3 RYBP S100A4 SAT1 SBF1 SEC13 SERTAD1 SF3A3 SF3B3 SLC7A9 SMARCA2 SMARCA4 SMARCD1 SNCA SNRNP200 SNRPF SPACA7 SPATA7 SPIN1 SPTBN1 SQSTM1 SRP72 STUB1 SUPT5H SYCE1 TARBP2 TARS1 TBC1D1 TBC1D3B TGFB1I1 TGM1 THOC5 TJP2 TMCO3 TOMM70 TOX4 TP53 TPT1 TRIM24 TRIM54 TSNAXIP1 TTC3 TTC39C TXNL1 UCHL5 UFD1 UQCC2 UQCRB VIM WASHC3 WDR83 WWP1 XPO1 XRCC5 YWHAB YWHAE YWHAH YWHAQ YWHAZ ZBTB17 ZBTB37 ZFAT ZNF131 ZNF197 ZNRF3
Entrez ID		1965	3315
HPRD ID		04881	09076
Ensembl ID		ENSG00000134001	ENSG00000106211
Uniprot IDs		P05198 Q53XC0	P04792 V9HW43
PDB IDs		1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z	2N3J 3Q9P 3Q9Q 4MJH 6DV5 6GJH
Enriched GO Terms of Interacting Partners?
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