EGR1 and SRA1

Number of citations of the paper that reports this interaction (PubMedID 20398657)
6

Data Source:
BioGRID (far western blotting)

		EGR1	SRA1
Description		early growth response 1	steroid receptor RNA activator 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Plasma Membrane Microtubule Cytoskeleton SCAR Complex Cell Leading Edge Intercellular Bridge Ribonucleoprotein Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding Promoter-specific Chromatin Binding	Steroid Receptor RNA Activator RNA Binding DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Response To Ischemia Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Glucose Positive Regulation Of Gene Expression T Cell Differentiation BMP Signaling Pathway Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Protein Sumoylation Skeletal Muscle Cell Differentiation Regulation Of Apoptotic Process Estrous Cycle Positive Regulation Of Chemokine Biosynthetic Process Locomotor Rhythm Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Biosynthetic Process Circadian Temperature Homeostasis Type I Interferon Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Cellular Response To Gamma Radiation Cellular Response To Heparin Cellular Response To Mycophenolic Acid Glomerular Mesangial Cell Proliferation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Interleukin-8 Positive Regulation Of Neuron Death Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Tau-protein Kinase Activity Regulation Of Progesterone Biosynthetic Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Mitotic Cell Cycle Cell Differentiation Regulation Of Apoptotic Process Negative Regulation Of Myoblast Differentiation Cellular Response To Estrogen Stimulus Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription NGF-stimulated transcription Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 28991256 25056061)	Schizophrenia ( 28991256)
Interacting Genes		23 interacting genes: CDKN2A CEBPB CRBN CREBBP CSNK2A1 DNMT3L EP300 ERBB3 IL1B JUN MTDH NAB1 NAB2 NFATC1 NFATC2 PITX1 PSMA3 RELA SP1 SRA1 SREBF2 TP53 WT1	30 interacting genes: ALX1 ATF1 ATF2 ATF3 ATF4 BLZF1 BTG2 CEBPA CREB1 DDIT3 DMTF1 E2F3 EGR1 EGR2 ESR1 ESR2 ESRRG ETS1 ETS2 FOS FOSB FOSL2 GATA1 GTF2B GTF2H2 GTF3C5 HAND1 NR3C1 TFAP2A UBE2Z
Entrez ID		1958	10011
HPRD ID		00549	18716
Ensembl ID		ENSG00000120738	ENSG00000213523
Uniprot IDs		P18146 Q546S1	Q9HD15
PDB IDs		4R2A 4R2C 4R2D 4X9J 5N14	2MGX 4NBO
Enriched GO Terms of Interacting Partners?
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