DSC1 and PKP2

Number of citations of the paper that reports this interaction (PubMedID 11790773)
73

Data Source:
HPRD (two hybrid)

		DSC1	PKP2
Description		desmocollin 1	plakophilin 2
Image
GO Annotations	Cellular Component	Cornified Envelope Plasma Membrane Cell-cell Junction Gap Junction Membrane Integral Component Of Membrane Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome Messenger Ribonucleoprotein Complex
	Molecular Function	Calcium Ion Binding Protein Binding	Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Keratinization Neutrophil Degranulation Cornification Cell-cell Adhesion	Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Heart Development Positive Regulation Of Sodium Ion Transport Keratinization Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Cornification Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell-cell Signaling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Multiple sclerosis ( 23412934)	Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)
Interacting Genes		8 interacting genes: DSG1 DSG2 DSP JUP PKP1 PKP2 PKP3 UCHL5	26 interacting genes: AKAP9 CASK CTNNB1 DDX11 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP GTF2IRD1 HSPB2 ITPR2 JUP KDM5A KLC4 KRT18 KRT5 MARK3 MTUS2 NDEL1 POLR3A RBM5 SINHCAF SMAD9 YWHAG
Entrez ID		1823	5318
HPRD ID		00511	04177
Ensembl ID		ENSG00000134765	ENSG00000057294
Uniprot IDs		Q08554 Q9HB00	Q99959
PDB IDs		5IRY	3TT9
Enriched GO Terms of Interacting Partners?
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