DRD5 and NCS1

Number of citations of the paper that reports this interaction (PubMedID 12351722)
69

Data Source:
HPRD (two hybrid)

		DRD5	NCS1
Description		dopamine receptor D5	neuronal calcium sensor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cilium Brush Border Membrane Synapse Ciliary Membrane Non-motile Cilium	Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Cell Junction Dendrite Dense Core Granule Intracellular Membrane-bounded Organelle Calyx Of Held Perinuclear Region Of Cytoplasm Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Adrenergic Receptor Activity Dopamine Neurotransmitter Receptor Activity Dopamine Binding	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Behavior Associative Learning Transmission Of Nerve Impulse Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Response To Cocaine Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Female Receptivity Sensitization Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Reactive Oxygen Species Metabolic Process	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis
Pathways		Dopamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Ziprasidone Cabergoline Cabergoline Ropinirole Olanzapine Olanzapine Mirtazapine Loxapine Loxapine Pramipexole Imipramine Chlorpromazine Chlorpromazine Cinnarizine Lisuride Ergotamine Apomorphine Trimipramine Fenoldopam Dopamine Dopamine Carphenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Methotrimeprazine Zuclopenthixol Rotigotine Mianserin Quinagolide	Calcium Citrate Calcium Phosphate
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Impulsivity (motor) ( 30718321) Lung cancer ( 28604730) Manganese levels ( 26025379) Metabolite levels ( 23823483)	Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)
Interacting Genes		5 interacting genes: GABRG2 GNA12 GNA13 GNAZ NCS1	10 interacting genes: DRD2 DRD3 DRD5 DTX2 EXOSC2 GRK2 IL1RAPL1 KCND2 NBL1 PI4KB
Entrez ID		1816	23413
HPRD ID		00542	04500
Ensembl ID		ENSG00000169676	ENSG00000107130
Uniprot IDs		P21918	A0A024R8B2 P62166
PDB IDs			1G8I 2LCP 4GUK 5O9S 6QI4
Enriched GO Terms of Interacting Partners?
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