DXO and EXOSC7

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DXO	EXOSC7
Description		decapping exoribonuclease	exosome component 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding MRNA Binding 5'-3' Exonuclease Activity RNA Pyrophosphohydrolase Activity	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding AU-rich Element Binding
	Biological Process	MRNA Catabolic Process RNA Destabilization Nuclear MRNA Surveillance Nucleic Acid Phosphodiester Bond Hydrolysis	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Catabolic Process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Disease progression in age-related macular degeneration ( 29346644) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Acne (severe) ( 24927181) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862)
Interacting Genes		8 interacting genes: EXOSC10 EXOSC4 EXOSC7 FLOT2 PRMT6 UPF1 XRN1 XRN2	15 interacting genes: APP DIS3 DXO EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC8 EXOSC9 IP6K1 MPHOSPH6 MPP6 MTREX
Entrez ID		1797	23016
HPRD ID		16186	09401
Ensembl ID		ENSG00000204348	ENSG00000075914
Uniprot IDs		A0A024RCW8 O77932	B2RDZ9 Q15024
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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