DNMT1 and HELLS

Number of citations of the paper that reports this interaction (PubMedID 17967891)
53

Data Source:
BioGRID (pull down)

		DNMT1	HELLS
Description		DNA methyltransferase 1	helicase, lymphoid specific
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin	Chromosome, Centromeric Region Nucleus Pericentric Heterochromatin
	Molecular Function	DNA Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity Promoter-specific Chromatin Binding	Helicase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Ras Protein Signal Transduction Maintenance Of DNA Methylation DNA Methylation On Cytosine Within A CG Sequence Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Silencing DNA Methylation Involved In Embryo Development Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine Positive Regulation Of Methylation-dependent Chromatin Silencing Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	Methylation-dependent Chromatin Silencing Cell Cycle Multicellular Organism Development Maintenance Of DNA Methylation Pericentric Heterochromatin Assembly Lymphocyte Proliferation Cell Division
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation
Drugs		Azacitidine Procainamide Flucytosine Decitabine Epigallocatechin Gallate
Diseases
GWAS		Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		40 interacting genes: AKT1 BAZ2A BRAP CBX1 CSNK2B DAXX DCAF5 DMAP1 DNASE2 DNM2 DNMT3A DNMT3B DYNLL1 E2F6 EED ELAVL3 EZH2 GSK3B H3-4 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 MECP2 NRIP1 PCNA PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUV39H1 TRIM27 TSG101 UBB YWHAQ	5 interacting genes: APP DNMT1 DNMT3B E2F3 HDAC1
Entrez ID		1786	3070
HPRD ID		00532	07232
Ensembl ID		ENSG00000130816	ENSG00000119969
Uniprot IDs		I6L9H2 P26358 Q59FP7	A0A087WSW7 A0A0B4J1V9 F6XU50 Q0VGL2 Q76H82 Q9NRZ9
PDB IDs		3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR
Enriched GO Terms of Interacting Partners?
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