DLG2 and CACNG2

Number of citations of the paper that reports this interaction (PubMedID 16637659)
25

Data Source:
HPRD (in vitro)

		DLG2	CACNG2
Description		discs large MAGUK scaffold protein 2	calcium voltage-gated channel auxiliary subunit gamma 2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Neuromuscular Junction Neuron Projection Perikaryon Juxtaparanode Region Of Axon Postsynaptic Density Membrane Glutamatergic Synapse Axon Cytoplasm	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cell Surface Cell Junction Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Cerebellar Mossy Fiber Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Guanylate Kinase Activity Protein Binding Kinase Binding Structural Constituent Of Postsynaptic Density	Voltage-gated Calcium Channel Activity Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	MAPK Cascade Chemical Synaptic Transmission Embryo Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Maintenance Of Postsynaptic Density Structure Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of NMDA Receptor Activity	Protein Targeting To Membrane Neuromuscular Junction Development Transmission Of Nerve Impulse Response To Calcium Ion Membrane Depolarization Membrane Hyperpolarization Eye Blink Reflex Cardiac Conduction Calcium Ion Transmembrane Transport Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Postsynaptic Neurotransmitter Receptor Diffusion Trapping Neurotransmitter Receptor Internalization Positive Regulation Of Protein Localization To Basolateral Plasma Membrane Regulation Of AMPA Receptor Activity Positive Regulation Of AMPA Receptor Activity
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Presynaptic depolarization and calcium channel opening Trafficking of AMPA receptors Phase 0 - rapid depolarisation Phase 2 - plateau phase LGI-ADAM interactions
Drugs			Ethanol
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Attention function in attention deficit hyperactive disorder ( 26174813) BMI at adiposity rebound ( 31840077) Body fat mass ( 28552196) Body mass index ( 28552196) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronic obstructive pulmonary disease ( 25584925) Chronic periodontitis ( 25008200) Familial squamous cell lung carcinoma ( 29924316) Height ( 28552196) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Migraine without aura ( 28952330) Mild influenza (H1N1) infection ( 26379185) Modic changes ( 30808802) Myopia ( 27182965) Obesity-related traits ( 23251661) Pallidum volume ( 31530798) Parkinson's disease ( 25064009 28892059 28011712 17052657) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Phospholipid levels (plasma) ( 22359512) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Protein quantitative trait loci ( 18464913) Putamen volume ( 29147026) Response to fenofibrate (triglyceride levels) ( 27002377) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Schizophrenia ( 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical brain region volumes ( 25607358) Trunk fat mass ( 28552196) Type 2 diabetes ( 31049640) Urate levels in overweight individuals ( 25811787) Weight ( 28552196) Wilms tumor ( 22544364)	Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)
Interacting Genes		40 interacting genes: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A	10 interacting genes: APP DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA4 PATJ PRKACA SRPK2
Entrez ID		1740	10369
HPRD ID		04663	04220
Ensembl ID		ENSG00000150672	ENSG00000166862
Uniprot IDs		B7Z2T4 E9PN83 Q15700	Q9Y698
PDB IDs		2BYG 2HE2	6DLZ 6DM0 6DM1 6O9G
Enriched GO Terms of Interacting Partners?
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