DEFA1 and PFDN1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		DEFA1	PFDN1
Description		defensin alpha 1	prefoldin subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Prefoldin Complex
	Molecular Function		DNA-binding Transcription Factor Activity Protein Binding Protein Binding Involved In Protein Folding Unfolded Protein Binding
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Immune Response T Cell Chemotaxis Antimicrobial Humoral Response Antibacterial Humoral Response Intracellular Estrogen Receptor Signaling Pathway Killing Of Cells Of Other Organism Defense Response To Protozoan Neutrophil Degranulation Pore Formation In Membrane Of Other Organism During Symbiotic Interaction Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Membrane Disruption In Other Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide	Regulation Of Transcription, DNA-templated Protein Folding
Pathways		Defensins Alpha-defensins Neutrophil degranulation	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Chromium levels ( 26025379) Dental caries (decayed and filled deciduous teeth) ( 31533690) Endometriosis ( 28333195) Periodontitis (PAL4Q3) ( 24024966)	Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		5 interacting genes: C1QB DEFA3 GSK3B PFDN1 SERPINF2	53 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		1667	5201
HPRD ID		00499	05357
Ensembl ID		ENSG00000206047	ENSG00000113068
Uniprot IDs		P59665	O60925
PDB IDs		2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0 4LB1 4LB7 4LBB 4LBF	6NR8 6NR9 6NRB 6NRC 6NRD
Enriched GO Terms of Interacting Partners?
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