DDIT3 and PCM1

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		DDIT3	PCM1
Description		DNA damage inducible transcript 3	pericentriolar material 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Late Endosome Cytosol Protein-DNA Complex CHOP-C/EBP Complex CHOP-ATF4 Complex CHOP-ATF3 Complex	Pericentriolar Material Cytoplasm Centrosome Centriole Cytosol Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Apical Part Of Cell Non-motile Cilium
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding CAMP Response Element Binding Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Maturation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus ER Overload Response Response To Unfolded Protein Cell Cycle Arrest Regulation Of Autophagy Wnt Signaling Pathway Positive Regulation Of Interleukin-8 Production Negative Regulation Of CREB Transcription Factor Activity Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Response To Starvation MRNA Transcription By RNA Polymerase II Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Transcription Involved In Anterior/posterior Axis Specification Cell Redox Homeostasis Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Kinase B Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Neuron Migration Centrosome Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Interkinetic Nuclear Migration Cytoplasmic Microtubule Organization Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Ciliary Basal Body-plasma Membrane Docking Non-motile Cilium Assembly
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Myxoid liposarcoma
GWAS			Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Waist-hip ratio ( 30108283) Weight ( 28552196)
Interacting Genes		61 interacting genes: AMOTL2 ATF2 ATF3 ATF4 ATPAF2 BACH1 BACH2 BATF BATF2 BATF3 CCDC153 CDK6 CEBPA CEBPB CEBPE CEBPG CREB3 CREB3L1 CSNK2A1 DBP DGCR2 DNMT3L EMSY EP300 EPAS1 F2 FOS FOSL1 FOSL2 GIPC1 GP1BA HOXA5 HSD17B14 IKBKG JUN JUNB JUND KPNA2 LMO2 MAFF MAFG MAPK14 MCMBP NFIL3 PCM1 PICALM POLR1D RAI1 RPS3 RPS3A SNAPC5 SPOP SRA1 SSX3 TEDC1 TNFSF12 TRIB3 VPS37C ZBTB25 ZC3H14 ZSCAN31	39 interacting genes: ABI1 ABI2 AKAP9 BBS4 CASK CCDC172 CCHCR1 CDC42 CEP72 DDIT3 DDX23 DYNLL1 E2F4 ECPAS EPS8 EXOC8 FXR2 GABARAP GOLGA2 HAP1 ING5 KLC1 KLC4 KRT15 KRT19 KRT24 NDC80 NECAB2 PCNT PRC1 PRKCI RBM5 RINT1 RPA2 TFIP11 TTC8 WASHC3 YWHAE YWHAQ
Entrez ID		1649	5108
HPRD ID		00529	02624
Ensembl ID		ENSG00000175197	ENSG00000078674
Uniprot IDs		P35638 Q53YD1	A2RUU9 B9EIS5 Q15154
PDB IDs			6HYL 6HYM
Enriched GO Terms of Interacting Partners?
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