DCTD and FGF12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DCTD	FGF12
Description		dCMP deaminase	fibroblast growth factor 12
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Space Nucleus Synapse
	Molecular Function	DCMP Deaminase Activity Protein Binding Zinc Ion Binding Identical Protein Binding	Protein Binding Growth Factor Activity Sodium Channel Regulator Activity Ion Channel Binding
	Biological Process	Pyrimidine Nucleotide Metabolic Process DUMP Biosynthetic Process DTMP Biosynthetic Process Nucleobase-containing Small Molecule Interconversion	Regulation Of Membrane Depolarization Signal Transduction Cell-cell Signaling Chemical Synaptic Transmission Nervous System Development Heart Development Adult Locomotory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transport Neuromuscular Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Neuronal Action Potential Regulation Of Sodium Ion Transmembrane Transport Regulation Of Voltage-gated Sodium Channel Activity Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity
Pathways		Interconversion of nucleotide di- and triphosphates	Phase 0 - rapid depolarisation
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Wegener's granulomatosis ( 23740775)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 28552196) Idiopathic dilated cardiomyopathy ( 29495422) Ileal carcinoids ( 21139019) Major depressive disorder ( 23377640) Metabolite levels ( 19043545) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum metabolite concentrations in chronic kidney disease ( 29545352) Severe influenza A (H1N1) infection ( 26379185) Sleep quality ( 23728906)
Interacting Genes		9 interacting genes: CEP76 FGF12 GORASP2 LNX1 MALSU1 NIF3L1 NUDT18 SDCBP TXN2	18 interacting genes: AP2M1 APP COIL DACH1 DCTD DPPA2 IKZF1 LZTS2 MAPK13 MAPK8IP2 NEDD4 NEDD4L PJA1 SMURF1 SRPK1 SRPK2 YWHAE ZNF460
Entrez ID		1635	2257
HPRD ID		09623	03303
Ensembl ID		ENSG00000129187	ENSG00000114279
Uniprot IDs		P32321	P61328
PDB IDs		2W4L	1Q1U 4JQ0
Enriched GO Terms of Interacting Partners?
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