SAXO1 and POLR1C

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SAXO1	POLR1C
Description		stabilizer of axonemal microtubules 1	RNA polymerase I and III subunit C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Centriole Cytoskeleton Axonemal Microtubule Motile Cilium Ciliary Basal Body Sperm Flagellum	Nucleoplasm RNA Polymerase III Complex RNA Polymerase I Complex Cytosol
	Molecular Function	Protein Binding Microtubule Binding	RNA Polymerase I Activity RNA Polymerase III Activity DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Cold Acclimation Cell Projection Organization Microtubule Anchoring Positive Regulation Of Cilium Assembly Protein Stabilization Cellular Response To Cold	Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Gene Expression, Epigenetic
Pathways			Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases			Treacher Collins syndrome
GWAS		Prudent dietary pattern ( 28644415)	GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: ACTN2 CRK FAM124A FHL2 FHL3 GLYCTK KIR3DX1 LMO1 LMO2 MVP OSGIN1 POLR1C SMARCB1 SORBS3 STK16 TRIP6 VPS28 ZMYND19	35 interacting genes: ATRIP BIRC7 CBY2 CCDC33 CD3EAP CLU CORO1A CORO1B IHO1 IKZF3 KCTD1 KRT19 LNX2 LZTS2 MBIP MKRN3 MYD88 MYO5B NFKBIB NME1 POLR1D POLR1E PPP2R3C RIMBP3 SAXO1 SMN2 TASOR2 TCF4 TFIP11 TNFAIP1 TRIM27 TRIOBP TSC22D4 VIM WRN
Entrez ID		158297	9533
HPRD ID		16676	09661
Ensembl ID		ENSG00000155875	ENSG00000171453
Uniprot IDs		B3KQ57 F6S232 Q5VZT6 Q8IYX7	O15160
PDB IDs
Enriched GO Terms of Interacting Partners?
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