CYLD and TRAIP

Number of citations of the paper that reports this interaction (PubMedID 14676304)
34

Data Source:
BioGRID (two hybrid, far western blotting)
HPRD (in vitro, in vivo, two hybrid)

		CYLD	TRAIP
Description		CYLD lysine 63 deubiquitinase	TRAF interacting protein
Image
GO Annotations	Cellular Component	Centrosome Spindle Cytosol Cytoplasmic Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Ciliary Tip	Nucleolus Perinuclear Region Of Cytoplasm
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Lys63-specific Deubiquitinase Activity Proline-rich Region Binding Lys48-specific Deubiquitinase Activity	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Protein Binding Innate Immune Response Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Negative Regulation Of JNK Cascade Homeostasis Of Number Of Cells Regulation Of Inflammatory Response Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Necroptotic Process Necroptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Negative Regulation Of NIK/NF-kappaB Signaling Regulation Of Cilium Assembly Negative Regulation Of P38MAPK Cascade Positive Regulation Of Cellular Protein Localization Protein Linear Deubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production
Pathways		NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Familial cylindromatosis Multiple familial trichoepithelioma Brooke-Spiegler syndrome
GWAS		Adventurousness ( 30643258) Asthma (childhood onset) ( 31036433) Asthma (time to onset) ( 27130862) Body mass index ( 28892062) Crohn's disease ( 28067908 22412388) Femoral neck bone mineral density ( 29499414) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Leprosy ( 25642632 22019778) Lumbar spine bone mineral density ( 29499414 22504420)	Blood protein levels ( 29875488 28240269) C-reactive protein levels ( 30388399) Extremely high intelligence ( 29520040) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mental health study participation (provided email address) ( 31263887) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Tea consumption ( 31046077)
Interacting Genes		22 interacting genes: AKT1 AURKB DDX58 DLG4 HDAC6 IKBKE IKBKG ITCH MAP3K7 MAPRE1 MIB2 PTPA TBK1 TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM47 TUBA1A UBC UBE2S	24 interacting genes: APP CYLD FLII MAGEF1 MAPRE2 PCNA POLK RNF114 RNF4 TNFRSF1B TRAF1 TRAF2 TRIM23 TRIM41 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2K UBE2U UBE2Z UBOX5 USP2
Entrez ID		1540	10293
HPRD ID		05427	05811
Ensembl ID		ENSG00000083799	ENSG00000183763
Uniprot IDs		A0A024R6T1 Q9NQC7	Q9BWF2
PDB IDs		1IXD 1WHL 1WHM 2VHF	4ZTD
Enriched GO Terms of Interacting Partners?
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