ADRB2 and ARHGDIA

Number of citations of the paper that reports this interaction (PubMedID 24561123)
3

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		ADRB2	ARHGDIA
Description		adrenoceptor beta 2	Rho GDP dissociation inhibitor alpha
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GO Annotations	Cellular Component	Nucleus Lysosome Endosome Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Receptor Complex	Cytosol Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Adrenergic Receptor Activity Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Epinephrine Binding Norepinephrine Binding	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Rac GTPase Binding
	Biological Process	Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Behavior Endosome To Lysosome Transport Response To Cold Positive Regulation Of Protein Kinase A Signaling Protein Deubiquitination Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Ubiquitination Heat Generation Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Membrane Organization Positive Regulation Of Mini Excitatory Postsynaptic Potential Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Autophagosome Maturation Positive Regulation Of Lipophagy Cellular Response To Amyloid-beta Response To Psychosocial Stress Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of AMPA Receptor Activity	Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization
Pathways		Adrenoceptors G alpha (s) signalling events Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis ADORA2B mediated anti-inflammatory cytokines production	Axonal growth inhibition (RHOA activation) Rho GTPase cycle Axonal growth stimulation
Drugs		Spermine Amphetamine Betaxolol Bethanidine Isoetarine Cabergoline Metoprolol Amitriptyline Olanzapine Atenolol Norepinephrine Mirtazapine Timolol Phenylpropanolamine Dipivefrin Sotalol Carteolol Nortriptyline Propranolol Labetalol Bisoprolol Epinephrine Trimipramine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Isoprenaline Arbutamine Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra Mephentermine Procaterol Clenbuterol Bambuterol Oxprenolol Putrescine Spermidine Celiprolol Nebivolol Indacaterol NCX 950 Asenapine Droxidopa Bufuralol (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Bopindolol Bupranolol Befunolol Olodaterol Vilanterol Tulobuterol Levosalbutamol
Diseases		Asthma
GWAS		Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 27863252) Peak expiratory flow ( 30804560) Systolic blood pressure ( 29615537)
Interacting Genes		92 interacting genes: ADGRG1 ADRB3 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 ARRDC3 CCKBR CD4 CD68 CD81 CD9 CEACAM1 CNN1 CSK EGLN3 EIF2B1 GMPR2 GNA11 GNA14 GNA15 GNAI2 GNAS GNAT2 GNB1 GNG2 GNL3L GPR37 GPRASP1 GPRC5B GRB2 GRIA3 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 HDAC6 HTR4 IL1B IL6R INSR KCNE1 KCNJ6 KCNJ9 KCTD13 MAPK8IP2 MCAM MDM2 NEDD4 NOS1 OPRD1 PLA2G2D PRKCD PTGER1 RAB27A RAB3A RACK1 RAN RAP2C REL RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RNF41 SLC52A2 SLC9A3R1 SLC9A3R2 SNCG SRC STAT3 STAT4 TSG101 TSHR UCHL1 VAPA VDAC1 VDAC2 VEGFB WNK1	41 interacting genes: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B EP300 FEN1 HAAO HDAC6 HERPUD1 IKBKG JUP KAT2B MAPK6 NEDD4L POT1 RAC1 RAC2 RAC3 RDX RHOA RHOG RHOH SDHC SH3GL3 SIRT2 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2I UBE2L6 UBE2R2 UFM1 VAV1
Entrez ID		154	396
HPRD ID		00187	03565
Ensembl ID		ENSG00000169252	ENSG00000141522
Uniprot IDs		P07550	J3QQX2 P52565 V9HWE8
PDB IDs		1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B 5D6L 5JQH 5X7D 6E67 6MXT 6N48 6NI3 6PRZ 6PS0 6PS1 6PS2 6PS3 6PS4 6PS5 6PS6	1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0 2N80
Enriched GO Terms of Interacting Partners?
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