COMMD1 and SLC12A2

Number of citations of the paper that reports this interaction (PubMedID 23515529)
6

Data Source:
BioGRID (two hybrid, pull down)

		COMMD1	SLC12A2
Description		copper metabolism domain containing 1	solute carrier family 12 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Cul2-RING Ubiquitin Ligase Complex Recycling Endosome	Cell Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome Extracellular Vesicle
	Molecular Function	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Sodium:potassium:chloride Symporter Activity Ammonium Transmembrane Transporter Activity Sodium Ion Transmembrane Transporter Activity Sodium:chloride Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding
	Biological Process	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface	Ion Transport Cell Volume Homeostasis Hyperosmotic Response Gamma-aminobutyric Acid Signaling Pathway Aging T Cell Chemotaxis Ammonium Transport Transepithelial Chloride Transport Sodium Ion Transmembrane Transport Positive Regulation Of Cell Volume Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Transepithelial Ammonium Transport Ammonium Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane Cellular Response To Chemokine
Pathways		Neddylation	Cation-coupled Chloride cotransporters
Drugs			Potassium Chloride Bumetanide Quinethazone
Diseases
GWAS		Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)	Beard thickness ( 26926045) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Height ( 25282103 31562340) Ileal carcinoids ( 21139019) Red cell distribution width ( 28957414) Statin-induced myopathy ( 31220337)
Interacting Genes		29 interacting genes: BAHCC1 BARD1 BRCA1 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC KAT2A LIG4 NFKBIA PRKN RELA SLC12A2 SOCS1 SOD1 SPP1 XIAP	3 interacting genes: COMMD1 OXSR1 STK39
Entrez ID		150684	6558
HPRD ID		06253	06775
Ensembl ID		ENSG00000173163	ENSG00000064651
Uniprot IDs		Q8N668	B7ZM24 P55011 Q53ZR1
PDB IDs		2H2M
Enriched GO Terms of Interacting Partners?
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