CTBP2 and TSHZ3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CTBP2	TSHZ3
Description		C-terminal binding protein 2	teashirt zinc finger homeobox 3
Image
GO Annotations	Cellular Component	Nucleus Transcriptional Repressor Complex Cell Junction Photoreceptor Ribbon Synapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse Presynaptic Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Plasma Membrane Growth Cone
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Kinase Binding Retinoic Acid Receptor Binding Protein-containing Complex Binding NAD Binding Structural Constituent Of Presynaptic Active Zone	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Cell Proliferation Synaptic Vesicle Docking Viral Genome Replication Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Maintenance Of Presynaptic Active Zone Structure White Fat Cell Differentiation Oxidation-reduction Process Cellular Response To Leukemia Inhibitory Factor	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation
Pathways		Repression of WNT target genes TCF7L2 mutants don't bind CTBP
Drugs
Diseases
GWAS		Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Body mass index ( 25673413 29273807) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Height ( 25429064) Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) ( 30188897) Menarche (age at onset) ( 25231870) Prostate cancer ( 18264096) Vigorous physical activity ( 29899525)	Adventurousness ( 30643258) Chronotype ( 30696823) Cognitive performance ( 19734545) Corneal astigmatism ( 30306274) Diastolic blood pressure ( 27841878) FEV1 ( 30804560) Fractional exhaled nitric oxide (childhood) ( 24315451) General risk tolerance (MTAG) ( 30643258) Lung function (FEV1/FVC) ( 30061609 30804560) Peak expiratory flow ( 30804560) Photic sneeze reflex ( 27182965) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Post bronchodilator FEV1 in COPD ( 26634245) Systemising ( 31508503) Systolic blood pressure ( 27841878) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		67 interacting genes: ACTG1 AKTIP APP ATE1 BAZ2B BCAS3 BCL3 C15orf39 CASP8AP2 CBX4 CCNH CCR5 CDKN2A CTBP1 CTPS2 DMRTB1 DVL2 EEF1D ELAC2 EP300 FHL3 FLI1 FOXP2 FUNDC1 H3-4 HIC1 HOXB5 IKZF2 KCNIP3 KLF3 KLF8 MDM2 MECOM NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 RAI2 RIMBP3 RPL17 RPL7A RPS28 RPS29 RPS4X RUNX1 SOX13 SOX6 STUB1 STX11 TEAD3 TGIF1 TSHZ3 UBC UBE2I XRCC6 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750	16 interacting genes: APBB1 CEP63 CEP70 CTBP1 CTBP2 KASH5 KRT40 MAD1L1 MTUS2 SPAG5 TAX1BP1 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54
Entrez ID		1488	57616
HPRD ID		04016	18351
Ensembl ID		ENSG00000175029	ENSG00000121297
Uniprot IDs		P56545	Q63HK5
PDB IDs		2OME 4LCJ	2DMI
Enriched GO Terms of Interacting Partners?
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