CRY2 and TIMELESS

Number of citations of the paper that reports this interaction (PubMedID 15798197)
107

Data Source:
HPRD (in vivo)

		CRY2	TIMELESS
Description		cryptochrome circadian regulator 2	timeless circadian regulator
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytosol Nuclear Speck	Nuclear Chromosome Nuclear Chromatin Nucleus Nucleoplasm Replication Fork Protection Complex Site Of Double-strand Break
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Phosphatase Binding FAD Binding	DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Protein-chromophore Linkage Negative Regulation Of Phosphoprotein Phosphatase Activity Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	DNA Replication Checkpoint Negative Regulation Of Transcription By RNA Polymerase II Morphogenesis Of An Epithelium DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Circadian Rhythm Detection Of Abiotic Stimulus Lung Development Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Replication Fork Arrest Cell Cycle Phase Transition Negative Regulation Of Transcription, DNA-templated Replication Fork Protection Branching Morphogenesis Of An Epithelial Tube Cell Division Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Bleomycin Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair
Pathways		Circadian Clock	Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Glycemic traits (pleiotropy) ( 31021400) Type 2 diabetes ( 30297969) Visceral fat ( 22589738)	Axial length ( 24144296) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Interacting Genes		22 interacting genes: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 DELEC1 EZH2 LMNA MTUS2 NPAS2 PDE9A PER1 PER2 PER3 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGES2 STK11 TIMELESS TTC1	9 interacting genes: CHEK1 CRY1 CRY2 PCBD1 PER1 PER2 TF TIPIN ZSCAN1
Entrez ID		1408	8914
HPRD ID		07226	04864
Ensembl ID		ENSG00000121671	ENSG00000111602
Uniprot IDs		A0A0D2X7Z3 A2I2P1 Q49AN0	Q9UNS1
PDB IDs			4XHT 4XHU 4XHW 5MQI
Enriched GO Terms of Interacting Partners?
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