CRKL and CD34

Number of citations of the paper that reports this interaction (PubMedID 11389015)
8

Data Source:
HPRD (in vitro, in vivo)

		CRKL	CD34
Description		CRK like proto-oncogene, adaptor protein	CD34 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Neuromuscular Junction Protein-containing Complex Extrinsic Component Of Postsynaptic Membrane	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Basal Plasma Membrane Apical Plasma Membrane Glomerular Endothelium Fenestra Intercellular Bridge Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding RNA Binding SH3/SH2 Adaptor Activity Protein Binding Identical Protein Binding Cadherin Binding	Transcription Factor Binding Carbohydrate Binding Sulfate Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Regulation Of Cell Growth Blood Vessel Development Urogenital System Development Neuron Migration B Cell Apoptotic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Lipid Metabolic Process JNK Cascade Ras Protein Signal Transduction Spermatogenesis Single Fertilization Synapse Assembly Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Anterior/posterior Pattern Specification Negative Regulation Of Gene Expression Dendrite Development Cytokine-mediated Signaling Pathway Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Helper T Cell Diapedesis Reelin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Retinoic Acid Receptor Signaling Pathway Thymus Development Regulation Of Dendrite Development T Cell Receptor Signaling Pathway Parathyroid Gland Development Cell Chemotaxis Pharynx Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Endothelin Receptor Signaling Pathway Activation Of GTPase Activity Acetylcholine Receptor Signaling Pathway Cerebellar Neuron Development Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Glial Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cranial Skeletal System Development Regulation Of T Cell Migration	Tissue Homeostasis Endothelial Cell Proliferation Glomerular Filtration Endothelium Development Cell-matrix Adhesion Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Hemopoiesis Negative Regulation Of Blood Coagulation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Mesangial Cell-matrix Adhesion Paracrine Signaling Positive Regulation Of Odontogenesis Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Cell Motility Regulation Of Immune Response Leukocyte Migration Transdifferentiation Vascular Wound Healing Hematopoietic Stem Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granulocyte Colony-stimulating Factor Production Extracellular Exosome Assembly Glomerular Endothelium Development Stem Cell Proliferation Metanephric Glomerular Mesangial Cell Differentiation Cell-cell Adhesion Negative Regulation Of Cellular Response To Heat Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Secretion Negative Regulation Of Neuron Death Positive Regulation Of Vasculogenesis
Pathways		Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
Drugs
Diseases
GWAS		Platelet distribution width ( 27863252)	Adventurousness ( 30643258) Age-related macular degeneration ( 23326517) Automobile speeding propensity ( 30643258) Drug experimentation measurement ( 30718321) Estimated glomerular filtration rate ( 31152163) Febrile seizures (MMR vaccine-related) ( 25344690) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Resting heart rate ( 27798624 20639392) RR interval (heart rate) ( 30679814) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		75 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RIN3 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 WAC WAS WIPF1 YY1	3 interacting genes: CHST4 CRKL PRKCD
Entrez ID		1399	947
HPRD ID		03596	00790
Ensembl ID		ENSG00000099942	ENSG00000174059
Uniprot IDs		P46109	P28906
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?
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