UHMK1 and PAM

Number of citations of the paper that reports this interaction (PubMedID 10574929)
13

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		UHMK1	PAM
Description		U2AF homology motif kinase 1	peptidylglycine alpha-amidating monooxygenase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Axon Midbody Dendrite Cytoplasm Neuronal Ribonucleoprotein Granule	Extracellular Region Trans-Golgi Network Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Transport Vesicle Membrane Secretory Granule Membrane Neuron Projection Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transferase Activity Ribonucleoprotein Complex Binding	Peptidylglycine Monooxygenase Activity Peptidylamidoglycolate Lyase Activity Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Protein Kinase Binding L-ascorbic Acid Binding Identical Protein Binding
	Biological Process	Cell Cycle Arrest Peptidyl-serine Phosphorylation Neuron Projection Development Positive Regulation Of Translational Initiation Protein Autophosphorylation Regulation Of Protein Export From Nucleus	Peptide Amidation Response To Hypoxia Long-chain Fatty Acid Metabolic Process Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Heart Development Lactation Response To PH Toxin Metabolic Process Response To Zinc Ion Protein Amidation Ovulation Cycle Process Response To Estradiol Regulation Of Actin Cytoskeleton Organization Odontogenesis Response To Drug Response To Copper Ion Regulation Of Protein Secretion Response To Glucocorticoid Oxidation-reduction Process Maternal Process Involved In Female Pregnancy Limb Development
Pathways		Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs			Vitamin C N-Alpha-Acetyl-3,5-Diiodotyrosylglycine Threonine Derivative
Diseases
GWAS		Bone mineral density (femoral neck) ( 27424934) Bone mineral density (total hip) ( 27424934) Discordance in emotional problems in monozygotic twins ( 27043157) Takayasu arteritis ( 25604533)	Blood protein levels ( 30072576 29875488) Diastolic blood pressure ( 29208002) Early cardiac repolarization ( 31600170) Feeling worry ( 29500382) Insulinogenic index ( 23263489) Medication use (drugs used in diabetes) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033) Primary biliary cholangitis ( 26394269) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 29208002) Type 2 diabetes ( 30054458 29358691 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		3 interacting genes: DEPDC1B PAM STMN1	10 interacting genes: CALM1 FXYD1 GLP1R KALRN POMC PRKCA RASSF9 TBCA TSC2 UHMK1
Entrez ID		127933	5066
HPRD ID		12318	01361
Ensembl ID		ENSG00000152332	ENSG00000145730
Uniprot IDs		Q8TAS1	O43832 P19021
PDB IDs
Enriched GO Terms of Interacting Partners?
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