CLTC and PXN

Number of citations of the paper that reports this interaction (PubMedID 10330411)
150

Data Source:
HPRD (in vitro)

		CLTC	PXN
Description		clathrin heavy chain	paxillin
Image
GO Annotations	Cellular Component	Lysosome Endosome Spindle Cytosol Plasma Membrane Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Protein-containing Complex Endolysosome Membrane Melanosome Clathrin-coated Endocytic Vesicle Extracellular Exosome Clathrin Complex Mitotic Spindle Extracellular Vesicle Mitotic Spindle Microtubule	Stress Fiber Cytosol Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium
	Molecular Function	RNA Binding Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding Ubiquitin-specific Protease Binding	Transcription Coregulator Activity Integrin Binding Protein Binding Beta-catenin Binding Vinculin Binding Protein Kinase Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Neuropilin Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Osteoblast Differentiation Intracellular Protein Transport Receptor-mediated Endocytosis Autophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Low-density Lipoprotein Particle Receptor Catabolic Process Transferrin Transport Low-density Lipoprotein Particle Clearance Retrograde Transport, Endosome To Golgi Clathrin Coat Assembly Cell Division Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Mitotic Spindle Organization Membrane Organization Clathrin-dependent Endocytosis Amyloid-beta Clearance By Transcytosis Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane	Muscle Contraction Cell Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription
Pathways		Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance	GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Platelet count ( 29403010)
Interacting Genes		56 interacting genes: AMPH AP1B1 AP1G1 AP3B1 AP3B2 ARMCX3 ARR3 ARRB1 ARRB2 C10orf88 CLINT1 CLTA CLTB DNAJC6 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 NCALD NDRG1 OCRL PICALM PPP1CA PPP1CC PRKACA PXN QARS1 SCYL2 SMAP1 SNX5 SNX9 SRC STAMBP SYNJ1 TFAP2A TNK2 TOM1 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9	78 interacting genes: ABL1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK IMPDH2 ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SCARB1 SDC4 SELE SORBS1 SRC SYK TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL
Entrez ID		1213	5829
HPRD ID		00350	03937
Ensembl ID		ENSG00000141367	ENSG00000089159
Uniprot IDs		A0A087WVQ6 Q00610	A0A140VJQ8 P49023
PDB IDs		2XZG 4G55 6E4L 6QNN 6QNP	1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6U4M 6U4N
Enriched GO Terms of Interacting Partners?
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