CLIC1 and ALOX5AP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CLIC1	ALOX5AP
Description		chloride intracellular channel 1	arachidonate 5-lipoxygenase activating protein
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Plasma Membrane Brush Border Membrane Nuclear Membrane Vesicle Chloride Channel Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding Cadherin Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Protein N-terminus Binding Arachidonic Acid Binding
	Biological Process	Chloride Transport Signal Transduction Regulation Of Ion Transmembrane Transport Positive Regulation Of Osteoblast Differentiation Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Platelet Aggregation Chloride Transmembrane Transport	Leukotriene Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Catalytic Activity Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification Lipoxin Biosynthetic Process
Pathways			Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX)
Drugs		Copper Artenimol	DG031 AM103
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Mean platelet volume ( 27863252) Ulcerative colitis ( 28067908)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) General risk tolerance (MTAG) ( 30643258) Non-word repetition ( 23738518)
Interacting Genes		20 interacting genes: AKAP9 ALOX5AP ATP5PB ATP6V0A1 ATP6V0C CPT1A DNAJC19 IKBKG LSM1 MYOC NTF4 NUP62 PRDX4 PSMD10 RPLP1 SUMO4 THRA TRAPPC2 ZNF184 ZNF302	4 interacting genes: ALOX5 CLIC1 GDF15 LTC4S
Entrez ID		1192	241
HPRD ID		04188	04742
Ensembl ID		ENSG00000213719	ENSG00000132965
Uniprot IDs		O00299 Q53FB0 Q5SRT3	A0A087WW23 P20292
PDB IDs		1K0M 1K0N 1K0O 1RK4 3O3T 3P8W 3P90 3QR6 3SWL 3TGZ 3UVH 4IQA 4JZQ 4K0G 4K0N	2Q7M 2Q7R
Enriched GO Terms of Interacting Partners?
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