CHRM4 and EEF1A2

Number of citations of the paper that reports this interaction (PubMedID 12048193)
6

Data Source:
HPRD (in vitro, in vivo)

		CHRM4	EEF1A2
Description		cholinergic receptor muscarinic 4	eukaryotic translation elongation factor 1 alpha 2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite Synapse Postsynaptic Membrane	Nucleus Cytoplasm Eukaryotic Translation Elongation Factor 1 Complex Neuronal Cell Body Synapse Cytoplasmic Side Of Lysosomal Membrane
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Protein Kinase Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Locomotion G Protein-coupled Serotonin Receptor Signaling Pathway	Translation Translational Elongation Response To Inorganic Substance Positive Regulation Of Apoptotic Process Response To Electrical Stimulus Positive Regulation Of Lipid Kinase Activity Regulation Of Chaperone-mediated Autophagy
Pathways		Muscarinic acetylcholine receptors G alpha (i) signalling events	Eukaryotic Translation Elongation
Drugs		Ziprasidone Amitriptyline Olanzapine Metixene Terfenadine Clozapine Trihexyphenidyl Procyclidine Loxapine Carbachol Promazine Hyoscyamine Pethidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine Methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Cryptenamine Tropicamide Brompheniramine Maprotiline Bethanechol Tolterodine Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine ALKS 27 Fesoterodine Hexocyclium Aclidinium Umeclidinium Dosulepin Etoperidone
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Prostate cancer ( 23535732)
Interacting Genes		3 interacting genes: EEF1A2 GPRASP1 GRB2	7 interacting genes: CHRM4 ERG MAPK6 SMN1 STK11 TPT1 TSPY1
Entrez ID		1132	1917
HPRD ID		00330	04265
Ensembl ID		ENSG00000180720	ENSG00000101210
Uniprot IDs		P08173	Q05639
PDB IDs		5DSG 6D9H	3C5J
Enriched GO Terms of Interacting Partners?
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