PNKP and GZMK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PNKP	GZMK
Description		polynucleotide kinase 3'-phosphatase	granzyme K
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane	Extracellular Region
	Molecular Function	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Nucleoside Monophosphate Kinase Activity	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Negative Regulation Of Protein ADP-ribosylation Dephosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Nucleoside Monophosphate Phosphorylation Positive Regulation Of Telomerase Activity Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation Positive Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Proteolysis Positive Regulation Of Apoptotic Process Negative Regulation Of Oxidoreductase Activity
Pathways		APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS			Blood protein levels ( 30072576 29875488)
Interacting Genes		17 interacting genes: APP GZMK IKZF1 KDM1A KRTAP4-12 LMNA MAGEA11 MYOZ1 POLB SMAD5 SUV39H1 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	12 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TUBB3 UFD1 VCP
Entrez ID		11284	3003
HPRD ID		09284	02872
Ensembl ID		ENSG00000039650	ENSG00000113088
Uniprot IDs		Q96T60	P49863
PDB IDs		2BRF 2W3O	1MZA 1MZD
Enriched GO Terms of Interacting Partners?
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