AKAP13 and GNA12

Number of citations of the paper that reports this interaction (PubMedID 11546812)
87

Data Source:
HPRD (in vivo, in vitro)

		AKAP13	GNA12
Description		A-kinase anchoring protein 13	G protein subunit alpha 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Actin Filament Cell Cortex Membrane Cortical Actin Cytoskeleton Perinuclear Region Of Cytoplasm	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Lateral Plasma Membrane Brush Border Membrane
	Molecular Function	CAMP-dependent Protein Kinase Activity MAP-kinase Scaffold Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rho GTPase Binding Metal Ion Binding Protein Kinase A Binding Molecular Adaptor Activity	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Heart Development Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Nuclear Export Cardiac Muscle Cell Differentiation Regulation Of Sarcomere Organization Bone Development Cell Growth Involved In Cardiac Muscle Cell Development Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Glucocorticoid Mediated Signaling Pathway	In Utero Embryonic Development G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Drug Embryonic Digit Morphogenesis
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	G alpha (12/13) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
Drugs
Diseases
GWAS		Birth weight ( 31043758) Central corneal thickness ( 31798171 29760442 20719862) Corneal structure ( 23291589) Coronary artery disease ( 29212778) Granulocyte percentage of myeloid white cells ( 27863252) Idiopathic pulmonary fibrosis ( 29066090) Intraocular pressure ( 29617998) Mean corpuscular volume ( 27863252) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Psoriasis ( 25939698) Pulse pressure ( 30578418) Response to platinum-based chemotherapy (carboplatin) ( 21844884) Systolic blood pressure ( 30578418)	Birth weight ( 31043758 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Daytime sleep phenotypes ( 27126917) Height ( 28552196 20881960 25282103 25429064 19343178 31562340 18391951 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Inflammatory bowel disease ( 28067908) Lateral ventricular volume in normal aging ( 30258056) Loneliness (linear analysis) ( 27629369) Monocyte count ( 27863252) Offspring birth weight ( 31043758) Platelet count ( 27863252) Plateletcrit ( 27863252) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 28067908 23128233 21297633) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Weight ( 28552196) White matter integrity ( 23218918)
Interacting Genes		22 interacting genes: APP CTNNAL1 ESR1 ESR2 GNA12 GNAQ LINC00839 MAP1LC3A PPARA PRKACA PRKAR2A PRKD1 RANBP2 RHOA RTKN RXRB SRPK2 THRA YWHAB YWHAE YWHAG YWHAZ	29 interacting genes: ACTB AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 S1PR4 S1PR5 TBXA2R TEC TSHR
Entrez ID		11214	2768
HPRD ID		05253	05093
Ensembl ID		ENSG00000170776	ENSG00000146535
Uniprot IDs		A8MYJ1 B0AZU4 Q12802	E9PC54 Q03113 Q6ZQV4
PDB IDs		2DRN 2LG1 4D0N 4D0O 6BCA
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?