NISCH and IRS4

Number of citations of the paper that reports this interaction (PubMedID 11912194)
11

Data Source:
HPRD (in vivo)

		NISCH	IRS4
Description		nischarin	insulin receptor substrate 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Plasma Membrane Membrane Recycling Endosome	Cytosol Plasma Membrane
	Molecular Function	Integrin Binding Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding	SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Glucose Metabolic Process Apoptotic Process Regulation Of Blood Pressure Rac Protein Signal Transduction Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Norepinephrine Secretion	Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction
Pathways			IRS-related events triggered by IGF1R
Drugs		Tizanidine Agmatine Moxonidine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) General cognitive ability ( 29844566) Parkinson's disease ( 28892059) Schizophrenia ( 25056061 29483656 23974872) Waist-hip ratio ( 20935629)
Interacting Genes		3 interacting genes: AR IRS4 ITGA5	21 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MTNR1A MTNR1B NDN NISCH PIK3CA PIK3R1 PRKCZ PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG
Entrez ID		11188	8471
HPRD ID		11391	04620
Ensembl ID		ENSG00000010322	ENSG00000133124
Uniprot IDs		Q9Y2I1	O14654
PDB IDs		3P0C
Enriched GO Terms of Interacting Partners?
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