EHMT2 and CCDC33

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EHMT2	CCDC33
Description		euchromatic histone lysine methyltransferase 2	coiled-coil domain containing 33
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding Promoter-specific Chromatin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Replication DNA Methylation Cellular Response To Starvation Histone Methylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Histone H3-K9 Methylation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Methylation RNA Polymerase I Transcription Initiation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Anti-thyroid drug induced agranulocytosis ( 27157822) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Chronic hepatitis B infection ( 25802187 23760081) Chronotype ( 30696823) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Takayasu arteritis ( 25604533) Type 2 diabetes ( 29358691) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)	Bacterial meningitis ( 31092817) Craniofacial microsomia ( 26853712) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Obesity-related traits ( 23251661) Systolic blood pressure ( 30578418)
Interacting Genes		48 interacting genes: ABHD17A AURKA CACNA1A CCDC33 CHCHD2 CSNK2A1 CUX1 DNMT3A E4F1 ESR1 FAM161A H1-1 H1-5 H3-3B H3-4 H3C1 H3C14 H3C15 HGS ITGB5 KLF12 KLF3 KLF6 LASP1 LIG1 LIMS1 LMO2 LNX1 MX2 NAA10 NAPRT PLOD3 POR PRRC2B PSMA1 RD3 RELB RERE RPA1 RUVBL2 THAP7 TP53 WIZ XAGE2 ZBTB38 ZNF512B ZNF688 ZNF785	102 interacting genes: ABCF3 ABLIM3 APP ARIH2 ARMC7 ARNT2 BCCIP BLK BLZF1 BYSL CALCOCO2 CCDC102B CCDC85B CCNH CDCA7L CDKN2B CENPP CHCHD3 CRYBA4 DGCR6 DIP2A DVL2 EAF1 EFEMP2 EHMT2 EMC2 EMD FAM124A FAM161A FXR2 GPATCH2L GRN HGS HNRNPF HNRNPK HOOK2 HOXA1 ING5 KANK2 KCTD19 KCTD9 KHDRBS3 KIFC3 KXD1 LDOC1 LMO2 LMO3 MAGED1 MAPK9 MDFI MIPOL1 MLH1 MOS NAB2 NCK2 NDOR1 NECAB2 NEFL NINL OSGIN1 PID1 PIK3R3 PIN1 PLSCR1 PNMA1 PNMA2 POLR1C PPP2R3C PRKAB2 PRPF31 PTGER3 PTK6 RAD51D RAD54B RBMX RHOXF2 RNF6 SCNM1 SMAD3 SMARCB1 SPAG5 SPG21 STK16 STX11 TGFB1 TMCC2 TRAF2 TRIM37 TRIM42 TSC22D4 TSGA10 TTC19 TUFT1 UBQLN4 USHBP1 VPS52 WT1 ZBTB8A ZGPAT ZNF572 ZNF688 ZNRD2
Entrez ID		10919	80125
HPRD ID		06854	09959
Ensembl ID		ENSG00000204371	ENSG00000140481
Uniprot IDs		A0A024RCN9 A2ABF8 B7Z852 Q59FM7 Q96KQ7	Q8N5R6
PDB IDs		2O8J 3DM1 3K5K 3RJW 4NVQ 5JHN 5JIN 5JIY 5JJ0 5T0K 5T0M 5TTF 5TUY 5V9I 5VSC 5VSE 6MM1
Enriched GO Terms of Interacting Partners?
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