USP20 and DIO2

Number of citations of the paper that reports this interaction (PubMedID 12865408)
52

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro, two hybrid)

		USP20	DIO2
Description		ubiquitin specific peptidase 20	iodothyronine deiodinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	Selenocysteine Incorporation Thyroid Hormone Generation Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Brown Fat Cell Differentiation Oxidation-reduction Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		Ub-specific processing proteases	Regulation of thyroid hormone activity
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)
Interacting Genes		28 interacting genes: ALAS1 BEND5 BEND7 CLSPN DIO2 FATE1 GTF2IRD1 HIF1A IHO1 LMNA MAGEA11 MAPK6 MDFI PJA1 PLA2G2A PRKACA PRKCI RAD17 SPRY2 STING1 TRIM23 UBC ULK1 USP15 USP21 USP28 VAPB VHL	6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1
Entrez ID		10868	1734
HPRD ID		07505	09027
Ensembl ID		ENSG00000136878	ENSG00000211448
Uniprot IDs		Q9Y2K6	A8K845 Q92813
PDB IDs		6KCZ
Enriched GO Terms of Interacting Partners?
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