GJB6 and GJB2

Number of citations of the paper that reports this interaction (PubMedID 14595769)
94

Data Source:
HPRD (in vivo)

		GJB6	GJB2
Description		gap junction protein beta 6	gap junction protein beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Cell Cytosol Actin Filament Gap Junction Connexin Complex Integral Component Of Membrane Apical Plasma Membrane Cell Junction	Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Integral Component Of Plasma Membrane Gap Junction Connexin Complex Lateral Plasma Membrane Cell Body Perinuclear Region Of Cytoplasm Astrocyte Projection
	Molecular Function	Gap Junction Channel Activity Microtubule Binding Beta-tubulin Binding Actin Filament Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling	Gap Junction Channel Activity Calcium Ion Binding Identical Protein Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
	Biological Process	Apoptotic Process Aging Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Cell Communication By Electrical Coupling Gap Junction Assembly Response To Lipopolysaccharide Ear Morphogenesis Inner Ear Development Response To Electrical Stimulus Transmembrane Transport Cellular Response To Glucose Stimulus Gap Junction-mediated Intercellular Transport	Response To Ischemia Cell-cell Signaling Aging Sensory Perception Of Sound Cell Communication By Electrical Coupling Gap Junction Assembly Response To Estradiol Response To Lipopolysaccharide Response To Retinoic Acid Response To Progesterone Cellular Response To Oxidative Stress Response To Human Chorionic Gonadotropin Response To Antibiotic Decidualization Inner Ear Development Transmembrane Transport Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Epididymis Development Gap Junction-mediated Intercellular Transport
Pathways		Gap junction assembly	Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly Transport of connexons to the plasma membrane
Drugs
Diseases		Ectodermal dysplasia, hidrotic; Clouston syndrome Deafness, autosomal recessive	Keratitis-ichthyosis-deafness syndrome Palmoplantar keratoderma with deafness Deafness, autosomal dominant Deafness, autosomal recessive Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis
GWAS		Facial emotion recognition (happy faces) ( 28608620)	Facial emotion recognition (happy faces) ( 28608620)
Interacting Genes		2 interacting genes: CNST GJB2	8 interacting genes: CAV1 CD14 CNST CREB3 GJB1 GJB6 LMNA NGLY1
Entrez ID		10804	2706
HPRD ID		05107	00413
Ensembl ID		ENSG00000121742	ENSG00000165474
Uniprot IDs		A0A024RDS4 O95452	H9U1J4 P29033
PDB IDs			1XIR 2ZW3 3IZ1 3IZ2 5ER7 5ERA 5KJ3 5KJG
Enriched GO Terms of Interacting Partners?
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