HBS1L and PELO

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		HBS1L	PELO
Description		HBS1 like translational GTPase	pelota mRNA surveillance and ribosome rescue factor
Image
GO Annotations	Cellular Component	Cytosol Membrane Extracellular Exosome	Nucleus Cytoplasm
	Molecular Function	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding	Endonuclease Activity Protein Binding Ribosome Binding Metal Ion Binding
	Biological Process	Translation Translational Elongation Signal Transduction Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Inner Cell Mass Cell Proliferation Cell Cycle Endoderm Development Stem Cell Population Maintenance Positive Regulation Of BMP Signaling Pathway Ribosome Disassembly Chromosome Organization Cell Division Mesenchymal To Epithelial Transition Nuclear-transcribed MRNA Catabolic Process, Non-stop Decay Nonfunctional RRNA Decay Nuclear-transcribed MRNA Catabolic Process, No-go Decay RNA Surveillance Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		mRNA decay by 3' to 5' exoribonuclease
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 29403010) Beta thalassemia/hemoglobin E disease ( 20183929) Cholesterol, total ( 24097068) Eosinophil counts ( 29403010 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736) Granulocyte count ( 27863252) HbA2 levels ( 23043469) Hematocrit ( 29403010 27863252 28017375 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010) Hemoglobin A1c levels ( 29403010) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hodgkin's lymphoma ( 24149102) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 23263863 29403010 19853236 28453575 20139978 27863252 28017375 28548082 19862010) Mean corpuscular hemoglobin concentration ( 23263863 29403010 20139978 27863252 28017375) Mean corpuscular volume ( 23263863 29403010 19853236 28453575 20139978 27863252 28017375 19862010) Metabolite levels ( 23823483) Monocyte count ( 27863252) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Other erythrocyte phenotypes ( 19862010) Platelet count ( 26805783 22139419 24026423 29066854 29403010 19853236 22423221 20139978 27863252) Plateletcrit ( 27863252) Red blood cell count ( 29403010 28453575 20139978 27863252 28017375) Red blood cell traits ( 20927387 23935956 23222517) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 30275531) White blood cell count ( 29403010 20139978 27863252) White blood cell types ( 21738478)	Acne (severe) ( 24927181) Birth weight ( 31043758) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Presence of antiphospholipid antibodies ( 23509613) Response to platinum-based agents ( 22020760) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Serum total protein level ( 29403010) Systolic blood pressure ( 27841878) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		10 interacting genes: APP EXOSC4 EXOSC5 EXOSC6 EXOSC9 MAP3K1 PELO SRPK1 SRPK2 UBE2G2	5 interacting genes: HBS1L HSPB1 PIK3R3 PRMT6 PTEN
Entrez ID		10767	53918
HPRD ID		06582	09309
Ensembl ID		ENSG00000112339	ENSG00000152684
Uniprot IDs		D9YZV0 Q9Y450	Q9BRX2
PDB IDs		5LZW 5LZX 5LZY 5LZZ	1X52 5EO3 5LZW 5LZX 5LZY 5LZZ
Enriched GO Terms of Interacting Partners?
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