MASP2 and SERPING1

Number of citations of the paper that reports this interaction (PubMedID 10946292)
48

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		MASP2	SERPING1
Description		mannan binding lectin serine peptidase 2	serpin family G member 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Calcium-dependent Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Proteolysis Complement Activation Complement Activation, Classical Pathway	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Aging Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Innate Immune Response
Pathways			Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Regulation of Complement cascade
Drugs		Beta-Hydroxyasparagine	C1-INH Copper
Diseases		Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency	Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS		Beard thickness ( 26926045) Body mass index ( 29273807) Male-pattern baldness ( 28196072)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576 29875488 28240269) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)
Interacting Genes		3 interacting genes: FCN2 MBL2 SERPING1	15 interacting genes: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2
Entrez ID		10747	710
HPRD ID		05484	06033
Ensembl ID		ENSG00000009724	ENSG00000149131
Uniprot IDs		O00187	E9KL26 P05155
PDB IDs		1Q3X 1SZB 1ZJK 3TVJ 4FXG 5JPM	1M6Q 2OAY 5DU3 5DUQ
Enriched GO Terms of Interacting Partners?
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