CD226 and NECTIN2

Number of citations of the paper that reports this interaction (PubMedID 12913096)
229

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		CD226	NECTIN2
Description		CD226 molecule	nectin cell adhesion molecule 2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Cell-cell Contact Zone Extracellular Exosome
	Molecular Function	Integrin Binding Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Interferon-gamma Production Positive Regulation Of Mast Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Spermatid Development Spermatid Nucleus Differentiation Fertilization Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Viral Entry Into Host Cell Coreceptor-mediated Virion Attachment To Host Cell Regulation Of Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases		Type I diabetes mellitus
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 23128233) Mean platelet volume ( 22139419 19820697 31194788 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Primary sclerosing cholangitis ( 23603763 27992413) Rheumatoid arthritis ( 30423114 24390342) Type 1 diabetes ( 21829393 25751624 17554260)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Low density lipoprotein cholesterol levels ( 30498476) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels ( 31578528)
Interacting Genes		4 interacting genes: FYN ITGB2 NECTIN2 PVR	20 interacting genes: AFDN ATP5MF CD226 DUS2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP5-9 LYRM4 MAPK6 MDFI NECTIN3 NECTIN4 NOTCH2NLA PICK1 PVR SIAH1 TIGIT USP53
Entrez ID		10666	5819
HPRD ID		09252	02879
Ensembl ID		ENSG00000150637	ENSG00000130202
Uniprot IDs		J3QR77 Q15762	Q92692
PDB IDs		6ISB 6O3O	3R0N 4DFH 4DFI 4HZA 5V52
Enriched GO Terms of Interacting Partners?
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