TXNIP and DDIT4

Number of citations of the paper that reports this interaction (PubMedID 21460850)
30

Data Source:
BioGRID (pull down, affinity chromatography technology, imaging technique)

		TXNIP	DDIT4
Description		thioredoxin interacting protein	DNA damage inducible transcript 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Intermembrane Space Cytosol	Intracellular Cytoplasm Mitochondrion Cytosol
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Cell Cycle Response To Mechanical Stimulus Response To Glucose Keratinocyte Differentiation Response To Estradiol Response To Progesterone Regulation Of Cell Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell	Response To Hypoxia Neuron Migration Apoptotic Process Brain Development Negative Regulation Of Peptidyl-threonine Phosphorylation Neuron Differentiation Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Protein-containing Complex Disassembly Negative Regulation Of Peptidyl-serine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Glycolytic Process Neurotrophin TRK Receptor Signaling Pathway Defense Response To Virus Cellular Response To Dexamethasone Stimulus Reactive Oxygen Species Metabolic Process Positive Regulation Of Neuron Death Negative Regulation Of Intracellular Signal Transduction
Pathways		The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection	TP53 Regulates Metabolic Genes
Drugs
Diseases
GWAS			Blond vs. brown/black hair color ( 30531825) Body mass index ( 31513605) Heschl's gyrus morphology ( 25130324)
Interacting Genes		18 interacting genes: DDIT4 ECD FHL1 HDAC1 HDAC3 HSPB2 ITCH KPNA2 NLGN3 PRKAA1 PTPN11 SCEL SMURF2 TXN TXNRD1 UBR5 ZBTB16 ZBTB32	7 interacting genes: GSK3B HSPA4 HSPB2 LRIF1 LRRK2 PDPK1 TXNIP
Entrez ID		10628	54541
HPRD ID		05964	09662
Ensembl ID		ENSG00000265972	ENSG00000168209
Uniprot IDs		Q9H3M7	A0A024QZQ6 Q9NX09
PDB IDs		4GEI 4GEJ 4GFX 4LL1 4LL4 4ROF 4ROJ 5CQ2 5DF6 5DWS 5DZD	3LQ9
Enriched GO Terms of Interacting Partners?
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