ZBTB18 and POMGNT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ZBTB18	POMGNT1
Description		zinc finger and BTB domain containing 18	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Nuclear Speck	Golgi Membrane Integral Component Of Membrane Integral Component Of Golgi Membrane
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Acetylglucosaminyltransferase Activity Manganese Ion Binding Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Skeletal Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Protein O-linked Glycosylation O-glycan Processing
Pathways			Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 O-linked glycosylation
Drugs
Diseases			Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Dystroglycanopathy; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama congenital muscular dystrophy (FCMD); Congenital muscular dystrophy with muscle hypertrophy (MDC1C); Congenital muscular dystrophy with severe intellectual impairment and abnormal glycosylation (MDC1D) Limb-girdle muscular dystrophy (LGMD)
GWAS		Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258) Mercury levels ( 26025379)	Body mass index ( 26426971)
Interacting Genes		7 interacting genes: CTBP1 CTBP2 DNMT3A DNMT3B PAK1 POMGNT1 TSN	5 interacting genes: BRCA1 CXCL8 LNX1 SOX6 ZBTB18
Entrez ID		10472	55624
HPRD ID		12231	09493
Ensembl ID		ENSG00000179456	ENSG00000085998
Uniprot IDs		Q99592	B7Z7F2 B7Z7Q4 Q8WZA1
PDB IDs			5GGF 5GGG 5GGI 5GGJ 5GGK 5GGL 5GGN 5GGO 5GGP 5XFC
Enriched GO Terms of Interacting Partners?
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