MAD2L2 and REV3L

Number of citations of the paper that reports this interaction (PubMedID 11485998)
93

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MAD2L2	REV3L
Description		mitotic arrest deficient 2 like 2	REV3 like, DNA directed polymerase zeta catalytic subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Nucleolus Spindle Cytosol Zeta DNA Polymerase Complex Site Of Double-strand Break	Nucleus Nucleoplasm Nucleolus Zeta DNA Polymerase Complex
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Protein Binding JUN Kinase Binding	Nucleotide Binding DNA Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Double-strand Break Repair Actin Filament Organization Mitotic Spindle Assembly Checkpoint Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Isotype Switching Positive Regulation Of Transcription, DNA-templated Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Double-strand Break Repair Via Homologous Recombination DNA-dependent DNA Replication Error-prone Translesion Synthesis Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
Drugs
Diseases
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738)	Inflammatory bowel disease ( 28067908 23128233) Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 26414677) Psoriasis ( 25574825) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908)
Interacting Genes		25 interacting genes: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 ELK1 FZR1 IKZF1 KCTD9 MAD2L1 MAD2L1BP POLDIP2 PRCC PRRC2A RBBP6 REL REV1 REV3L SFI1 SHLD1 SHLD2 TCF4 TRIM27 YY1AP1	6 interacting genes: CHEK2 HDAC2 HDAC4 MAD2L1 MAD2L2 REV1
Entrez ID		10459	5980
HPRD ID		07246	04145
Ensembl ID		ENSG00000116670	ENSG00000009413
Uniprot IDs		A0A024R4I4 Q9UI95	O60673 Q9UG47
PDB IDs		3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6KEA 6NIF	3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5O8K 6BC8 6BCD 6BI7 6EKM 6KEA
Enriched GO Terms of Interacting Partners?
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