APC2 and AXIN2

Number of citations of the paper that reports this interaction (PubMedID 10021369)
34

Data Source:
BioGRID (two hybrid)

		APC2	AXIN2
Description		APC regulator of WNT signaling pathway 2	axin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Microtubule Actin Filament Microtubule Cytoskeleton Catenin Complex Midbody Beta-catenin Destruction Complex Lamellipodium Membrane Filamentous Actin Intercellular Bridge Perinuclear Region Of Cytoplasm Postsynapse	Nucleus Cytoplasm Centrosome Cytosol Beta-catenin Destruction Complex
	Molecular Function	Protein Binding Beta-catenin Binding Microtubule Binding Gamma-catenin Binding	Protein Binding Beta-catenin Binding Enzyme Binding Ubiquitin Protein Ligase Binding I-SMAD Binding
	Biological Process	Microtubule Cytoskeleton Organization Cell Fate Specification Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Wnt Signaling Pathway Cell Migration Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Activation Of GTPase Activity	Somitogenesis Positive Regulation Of Protein Phosphorylation Intramembranous Ossification Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Death Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Cellular Protein Localization Odontogenesis Maintenance Of DNA Repeat Elements Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways			TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases
Drugs
Diseases		Colorectal cancer	Tooth agenesis; Hypodontia Oligodontia-colorectal cancer syndrome
GWAS		Lean body mass ( 28552196)	Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549 28869591) Height ( 31562340)
Interacting Genes		4 interacting genes: AXIN2 CTNNB1 MAPRE1 MAPRE3	9 interacting genes: ANKRD6 APC APC2 CSNK1E CTNNB1 GSK3B SLC9A3R1 SMAD3 SMAD7
Entrez ID		10297	8313
HPRD ID		09802	04935
Ensembl ID		ENSG00000115266	ENSG00000168646
Uniprot IDs		O95996	E7ES00 Q9Y2T1
PDB IDs
Enriched GO Terms of Interacting Partners?
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